Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)

BACKGROUND: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards. METHODS: Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested...

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Detalles Bibliográficos
Autores principales: Honkaniemi, E, Talekar, G, Huang, W, Bogdanovic, G, Forestier, E, von Doblen, U, Engvall, M, Ornelles, D A, Gooding, L R, Gustafsson, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833262/
https://www.ncbi.nlm.nih.gov/pubmed/20197772
http://dx.doi.org/10.1038/sj.bjc.6605581
Descripción
Sumario:BACKGROUND: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards. METHODS: Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested polymerase chain reaction for the presence of adenovirus DNA. RESULTS: Adenovirus DNA was reliably detected from only two subjects, both of whom developed ALL. CONCLUSION: Adenovirus DNA is detected in Guthrie card samples at too low a frequency to reveal an association between adenovirus and the development of leukaemia.

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