Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)

BACKGROUND: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards. METHODS: Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested...

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Autores principales: Honkaniemi, E, Talekar, G, Huang, W, Bogdanovic, G, Forestier, E, von Doblen, U, Engvall, M, Ornelles, D A, Gooding, L R, Gustafsson, B
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833262/
https://www.ncbi.nlm.nih.gov/pubmed/20197772
http://dx.doi.org/10.1038/sj.bjc.6605581
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author Honkaniemi, E
Talekar, G
Huang, W
Bogdanovic, G
Forestier, E
von Doblen, U
Engvall, M
Ornelles, D A
Gooding, L R
Gustafsson, B
author_facet Honkaniemi, E
Talekar, G
Huang, W
Bogdanovic, G
Forestier, E
von Doblen, U
Engvall, M
Ornelles, D A
Gooding, L R
Gustafsson, B
author_sort Honkaniemi, E
collection PubMed
description BACKGROUND: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards. METHODS: Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested polymerase chain reaction for the presence of adenovirus DNA. RESULTS: Adenovirus DNA was reliably detected from only two subjects, both of whom developed ALL. CONCLUSION: Adenovirus DNA is detected in Guthrie card samples at too low a frequency to reveal an association between adenovirus and the development of leukaemia.
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spelling pubmed-28332622011-03-02 Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL) Honkaniemi, E Talekar, G Huang, W Bogdanovic, G Forestier, E von Doblen, U Engvall, M Ornelles, D A Gooding, L R Gustafsson, B Br J Cancer Short Communication BACKGROUND: In search of a proposed viral aetiology of childhood acute lymphoblastic leukaemia (ALL), the common species C adenoviruses were analysed in Guthrie cards. METHODS: Guthrie cards from 243 children who later developed ALL and from 486 matched controls were collected and analysed by nested polymerase chain reaction for the presence of adenovirus DNA. RESULTS: Adenovirus DNA was reliably detected from only two subjects, both of whom developed ALL. CONCLUSION: Adenovirus DNA is detected in Guthrie card samples at too low a frequency to reveal an association between adenovirus and the development of leukaemia. Nature Publishing Group 2010-03-02 2010-03-02 /pmc/articles/PMC2833262/ /pubmed/20197772 http://dx.doi.org/10.1038/sj.bjc.6605581 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Honkaniemi, E
Talekar, G
Huang, W
Bogdanovic, G
Forestier, E
von Doblen, U
Engvall, M
Ornelles, D A
Gooding, L R
Gustafsson, B
Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)
title Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)
title_full Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)
title_fullStr Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)
title_full_unstemmed Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)
title_short Adenovirus DNA in Guthrie cards from children who develop acute lymphoblastic leukaemia (ALL)
title_sort adenovirus dna in guthrie cards from children who develop acute lymphoblastic leukaemia (all)
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833262/
https://www.ncbi.nlm.nih.gov/pubmed/20197772
http://dx.doi.org/10.1038/sj.bjc.6605581
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