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B cell abnormalities in systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoantibodies. Ectopic germinal centers and plasma cells secreting autoantibodies have been obs...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2003
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833441/ https://www.ncbi.nlm.nih.gov/pubmed/15180894 http://dx.doi.org/10.1186/ar1009 |
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author | Grammer, Amrie C Lipsky, Peter E |
author_facet | Grammer, Amrie C Lipsky, Peter E |
author_sort | Grammer, Amrie C |
collection | PubMed |
description | Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoantibodies. Ectopic germinal centers and plasma cells secreting autoantibodies have been observed in lupus nephritis kidneys. Candidate genetic susceptibility loci for SLE include genes that affect differentiation and survival of plasma cells, such as those that influence activation, proliferation, cytokine and chemokine secretion/responsiveness, and apoptosis of the T and B cells that are involved in humoral immunity generated in germinal centers, as well as genes that are involved in presentation and clearance of apoptotic material and autoantigens by antigen presenting cells and other phagocytes. Emerging data have demonstrated that B lymphocytes are active participants in humoral immune responses that lead to T-dependent and T-independent differentiation of immunoglobulin-secreting plasma cells by homotypic CD154–CD40 interactions as well as continued stimulation by B cell activating factor through B cell maturation antigen, B cell activating factor receptor and transmembrane activater. |
format | Text |
id | pubmed-2833441 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2003 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28334412010-03-08 B cell abnormalities in systemic lupus erythematosus Grammer, Amrie C Lipsky, Peter E Arthritis Res Ther Review Systemic lupus erythematosus (SLE) is a chronic, multisystem autoimmune disease characterized by the differentiation of short- and long-lived immunoglobulin secreting plasma cells that secrete pathogenic autoantibodies. Ectopic germinal centers and plasma cells secreting autoantibodies have been observed in lupus nephritis kidneys. Candidate genetic susceptibility loci for SLE include genes that affect differentiation and survival of plasma cells, such as those that influence activation, proliferation, cytokine and chemokine secretion/responsiveness, and apoptosis of the T and B cells that are involved in humoral immunity generated in germinal centers, as well as genes that are involved in presentation and clearance of apoptotic material and autoantigens by antigen presenting cells and other phagocytes. Emerging data have demonstrated that B lymphocytes are active participants in humoral immune responses that lead to T-dependent and T-independent differentiation of immunoglobulin-secreting plasma cells by homotypic CD154–CD40 interactions as well as continued stimulation by B cell activating factor through B cell maturation antigen, B cell activating factor receptor and transmembrane activater. BioMed Central 2003 2003-12-02 /pmc/articles/PMC2833441/ /pubmed/15180894 http://dx.doi.org/10.1186/ar1009 Text en Copyright ©2003 BioMed Central Ltd |
spellingShingle | Review Grammer, Amrie C Lipsky, Peter E B cell abnormalities in systemic lupus erythematosus |
title | B cell abnormalities in systemic lupus erythematosus |
title_full | B cell abnormalities in systemic lupus erythematosus |
title_fullStr | B cell abnormalities in systemic lupus erythematosus |
title_full_unstemmed | B cell abnormalities in systemic lupus erythematosus |
title_short | B cell abnormalities in systemic lupus erythematosus |
title_sort | b cell abnormalities in systemic lupus erythematosus |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833441/ https://www.ncbi.nlm.nih.gov/pubmed/15180894 http://dx.doi.org/10.1186/ar1009 |
work_keys_str_mv | AT grammeramriec bcellabnormalitiesinsystemiclupuserythematosus AT lipskypetere bcellabnormalitiesinsystemiclupuserythematosus |