Cargando…

IL-18 directly promotes joint inflammation and induces cartilage destruction through IL-1

Detalles Bibliográficos
Autores principales:	Joosten, L, Lubberts, E, Wagenmans, MJM, Helsen, MMA, van de Loo, FAJ, van den Berg, WB
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2003
Materias:	Meeting Abstract
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833610/ http://dx.doi.org/10.1186/ar673

Ejemplares similares

Local IL-18 gene transfer prevents severe joint destruction in murine collagen-induced arthritis by induction of IL-4 and osteoprotegerin
por: Joosten, LAB, et al.
Publicado: (2005)

Local interleukin-12 gene transfer promotes conversion of an acute to a chronic destructive murine streptococcal cell wall arthritis
por: Joosten, LAB, et al.
Publicado: (2001)

Endogenous IL-12p40 is crucial for antigen-induced arthritis and is partly involved in chronic relapsing streptococcal-cell-wall arthritis
por: Jacobs, M, et al.
Publicado: (2003)

IL-18 blockade is a potential disease-modifying therapy for rheumatoid arthritis
por: Plater-Zyberk, C, et al.
Publicado: (2001)

IL-1-dependent cartilage damage in a macrophage-driven arthritis model can be circumvented by T cell IL-17
por: Koenders, MI, et al.
Publicado: (2004)

IL-1-driven cartilage and bone destruction are dependent on Toll-like receptor (TLR) 4, but not TLR2
por: Abdollahi-Roodsaz, S, et al.
Publicado: (2005)

Adenoviral transfer of murine OncostatinM induces inflammation and bone apposition in joints of IL-1, IL-6 and TNF-α deficient mice
por: de Hooge, ASK, et al.
Publicado: (2002)

Neutralizing synovial RANKL by local OPG gene therapy in collagen-induced arthritis prevents cartilage erosion through induction of a non-destructive type 2 synovitis
por: Lubberts, E, et al.
Publicado: (2004)

IL-18 expression in synovial biopsies of patients with active rheumatoid arthritis is associated with enhanced levels of both IL-1 and TNFα
por: Joosten, LAB, et al.
Publicado: (2002)

Local inhibition of endogenous IL-18 through adenoviral overexpression of IL-18BPc results in reduced incidence and severity of collagen induced arthritis in mice
por: Smeets, RL, et al.
Publicado: (2002)

Reporter cell lines for real-time imaging of NF-κB activation in the arthritic joint
por: Smeets, RL, et al.
Publicado: (2004)

Genome-wide gene expression in experimental arthritis: defining new targets of chronic/destructive rheumatoid arthritis (RA)
por: Takahashi, N, et al.
Publicado: (2002)

TNF-α dependency of IL-17-induced joint pathology differs under naive and arthritis conditions in vivo
por: Koenders, M, et al.
Publicado: (2003)

inflammation-inducible intra-articular production of human IL-1 receptor antagonist results in a more efficient inhibition of collagen-induced arthritis than does constitutive expression of the same transgene
por: Bakker, AC, et al.
Publicado: (2001)

Neutralizing IL-17 during re-activation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and IL-1
por: Koenders, MI, et al.
Publicado: (2005)

Using a tropism-modified adenoviral vector for the intra-articular production of IL-1 receptor antagonist results in a more efficient inhibition of collagen-induced arthritis than does a conventional Ad5 vector
por: Bakker, AC, et al.
Publicado: (2001)

Suppressor of cytokine signaling (SOCS)-3 gene transfer protects against collagen-induced arthritis
por: van de Loo, FAJ, et al.
Publicado: (2004)

Identification of a natural soluble form of the IL-18 receptor accessory protein as an immunomodulator in experimental arthritis
por: Smeets, RL, et al.
Publicado: (2005)

Local IL-17 gene therapy accelerates collagen arthritis with severe bone erosion and rank ligand and rank expression in synovial infiltrate and at bone erosion sites
por: Lubberts, E, et al.
Publicado: (2001)

Requirement of IL-17 receptor signaling in resident synoviocytes for development of full blown destructive arthritis
por: Lubberts, E, et al.
Publicado: (2005)

Requirement of local synovial IL-17 receptor signaling in the progression of chronic synovitis and bone erosion in arthritis
por: Lubberts, E, et al.
Publicado: (2004)

Role of Cytokines in Cartilage Destruction in Experimental Arthritis
por: van den Berg, Wim B
Publicado: (2000)

Activating FcγRIII determines cartilage destruction during immune complex arthritis but not in the presence of T-cell immunity
por: van Lent, PLEM, et al.
Publicado: (2002)

Interleukin-1 receptor antagonist lentiviral gene transfer to the murine knee joint ameliorates collagen-induced arthritis
por: van de Loo, FAJ, et al.
Publicado: (2005)

Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
por: Joosten, Leo AB, et al.
Publicado: (1999)

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
por: Chabaud, Martine, et al.
Publicado: (2001)

TNF dependency of IL-17-induced joint pathology can be circumvented by Toll-like receptor-2 signaling
por: Van den Berg, W, et al.
Publicado: (2003)

Efficient IL-18 and IL-18BPc adenoviral gene transfer to cultured murine submandibular gland epithelial cells and successful murine retrograde submandibular duct cannulation to modulate IL-18 function in the salivary gland of animal models of Sjogren's syndrome
por: Bombardieri, M, et al.
Publicado: (2005)

IL-13 overexpression during immune complex arthritis diminishes MMP-mediated VDIPEN expression
por: Nabbe, KC, et al.
Publicado: (2004)

Citrullination of synovial proteins in murine models of rheumatoid arthritis
por: Vossenaar, E, et al.
Publicado: (2003)

A polymorphism in the IL-10 promoter affects autoantibody production and subsequent joint destruction in rheumatoid arthritis
por: van Gaalen, FA, et al.
Publicado: (2003)

Isolated and combined inhibition of TNF-, IL-1 and RANKL-pathways in TNF-induced arthritis: effects on synovial inflammation, bone erosion and cartilage destruction
por: Zwerina, J, et al.
Publicado: (2003)

Transfer of protease inhibitors to inhibit cartilage destruction
por: van der Laan, WH, et al.
Publicado: (2001)

Effect of IL-18 on synovial cell subsets and its regulation by IL-18BP
por: Kawashima, M, et al.
Publicado: (2002)

The inhibitory receptor FcγRII reduces joint inflammation in immune complex arthritis not only by inhibition of activatory FcγR but also by efficient clearance of immune complexes
por: van Lent, PL, et al.
Publicado: (2003)

IL-17 produced by Paneth cells drives TNF-induced shock
por: Takahashi, Nozomi, et al.
Publicado: (2008)

Invasion of synoviocytes is inhibited by gene transfer of TNF-BP or IL10 in an in vitro invasion model
por: Pieterman, E, et al.
Publicado: (2001)

OR11-004 - IL-1, IL-18 and cell death in NLRP3 driven disease
por: Broderick, L, et al.
Publicado: (2013)

Higher efficacy of anti-IL-6/IL-21 combination therapy compared to monotherapy in the induction phase of Th17-driven experimental arthritis
por: Roeleveld, Debbie M., et al.
Publicado: (2017)

Toll-like receptor 4 polymorphism influences susceptibility to but not severity and outcome of rheumatoid arthritis
por: Radstake, TRDJ, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_11pccua934436t2vv1d39g1i6p