The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis

Abatacept (CTLA4–Ig) is a novel fusion protein designed to modulate the T cell co-stimulatory signal mediated through the CD28–CD80/86 pathway. Clinical trials have provided preliminary evidence of the efficacy of this compound in the treatment of rheumatoid arthritis. This review describes the mole...

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Detalles Bibliográficos
Autores principales: Ruderman, Eric M, Pope, Richard M
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833980/
https://www.ncbi.nlm.nih.gov/pubmed/15833145
http://dx.doi.org/10.1186/ar1688
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author Ruderman, Eric M
Pope, Richard M
author_facet Ruderman, Eric M
Pope, Richard M
author_sort Ruderman, Eric M
collection PubMed
description Abatacept (CTLA4–Ig) is a novel fusion protein designed to modulate the T cell co-stimulatory signal mediated through the CD28–CD80/86 pathway. Clinical trials have provided preliminary evidence of the efficacy of this compound in the treatment of rheumatoid arthritis. This review describes the molecular and biologic bases for the use of abatacept in rheumatoid arthritis and summarizes the current clinical data on its safety and effectiveness in this disease.
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spelling pubmed-28339802010-03-08 The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis Ruderman, Eric M Pope, Richard M Arthritis Res Ther Review Abatacept (CTLA4–Ig) is a novel fusion protein designed to modulate the T cell co-stimulatory signal mediated through the CD28–CD80/86 pathway. Clinical trials have provided preliminary evidence of the efficacy of this compound in the treatment of rheumatoid arthritis. This review describes the molecular and biologic bases for the use of abatacept in rheumatoid arthritis and summarizes the current clinical data on its safety and effectiveness in this disease. BioMed Central 2005 2005-03-16 /pmc/articles/PMC2833980/ /pubmed/15833145 http://dx.doi.org/10.1186/ar1688 Text en Copyright ©2005 BioMed Central Ltd
spellingShingle Review
Ruderman, Eric M
Pope, Richard M
The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
title The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
title_full The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
title_fullStr The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
title_full_unstemmed The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
title_short The evolving clinical profile of abatacept (CTLA4–Ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
title_sort evolving clinical profile of abatacept (ctla4–ig): a novel co-stimulatory modulator for the treatment of rheumatoid arthritis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2833980/
https://www.ncbi.nlm.nih.gov/pubmed/15833145
http://dx.doi.org/10.1186/ar1688
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