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Chromatin regulation in drug addiction and depression

Alterations in gene expression are implicated in the pathogenesis of several neuropsychiatrie disorders, including drug addiction and depression, increasing evidence indicates that changes in gene expression in neurons, in the context of animal models of addiction and depression, are mediated in par...

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Detalles Bibliográficos
Autores principales: Renthal, William, Nestler, Eric J.
Formato: Texto
Lenguaje:English
Publicado: Les Laboratoires Servier 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834246/
https://www.ncbi.nlm.nih.gov/pubmed/19877494
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author Renthal, William
Nestler, Eric J.
author_facet Renthal, William
Nestler, Eric J.
author_sort Renthal, William
collection PubMed
description Alterations in gene expression are implicated in the pathogenesis of several neuropsychiatrie disorders, including drug addiction and depression, increasing evidence indicates that changes in gene expression in neurons, in the context of animal models of addiction and depression, are mediated in part by epigenetic mechanisms that alter chromatin structure on specific gene promoters. This review discusses recent findings from behavioral, molecular, and bioinformatic approaches that are being used to understand the complex epigenetic regulation of gene expression in brain by drugs of abuse and by stress. These advances promise to open up new avenues for improved treatments of these disorders.
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spelling pubmed-28342462010-03-08 Chromatin regulation in drug addiction and depression Renthal, William Nestler, Eric J. Dialogues Clin Neurosci Translational Research Alterations in gene expression are implicated in the pathogenesis of several neuropsychiatrie disorders, including drug addiction and depression, increasing evidence indicates that changes in gene expression in neurons, in the context of animal models of addiction and depression, are mediated in part by epigenetic mechanisms that alter chromatin structure on specific gene promoters. This review discusses recent findings from behavioral, molecular, and bioinformatic approaches that are being used to understand the complex epigenetic regulation of gene expression in brain by drugs of abuse and by stress. These advances promise to open up new avenues for improved treatments of these disorders. Les Laboratoires Servier 2009-09 /pmc/articles/PMC2834246/ /pubmed/19877494 Text en Copyright: © 2009 LLS http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc-nd/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Translational Research
Renthal, William
Nestler, Eric J.
Chromatin regulation in drug addiction and depression
title Chromatin regulation in drug addiction and depression
title_full Chromatin regulation in drug addiction and depression
title_fullStr Chromatin regulation in drug addiction and depression
title_full_unstemmed Chromatin regulation in drug addiction and depression
title_short Chromatin regulation in drug addiction and depression
title_sort chromatin regulation in drug addiction and depression
topic Translational Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834246/
https://www.ncbi.nlm.nih.gov/pubmed/19877494
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