Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase

Androgen deprivation therapy (ADT) facilitates the response of prostate cancer (PC) to radiation. Androgens have been shown to induce elevated basal levels of reactive oxygen species (ROS) in PC, leading to adaptation to radiation-induced cytotoxic oxidative stress. Here, we show that androgens incr...

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Detalles Bibliográficos
Autores principales: Lu, J P, Monardo, L, Bryskin, I, Hou, Z F, Trachtenberg, J, Wilson, B C, Pinthus, J H
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2009
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834342/
https://www.ncbi.nlm.nih.gov/pubmed/19546883
http://dx.doi.org/10.1038/pcan.2009.24
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author Lu, J P
Monardo, L
Bryskin, I
Hou, Z F
Trachtenberg, J
Wilson, B C
Pinthus, J H
author_facet Lu, J P
Monardo, L
Bryskin, I
Hou, Z F
Trachtenberg, J
Wilson, B C
Pinthus, J H
author_sort Lu, J P
collection PubMed
description Androgen deprivation therapy (ADT) facilitates the response of prostate cancer (PC) to radiation. Androgens have been shown to induce elevated basal levels of reactive oxygen species (ROS) in PC, leading to adaptation to radiation-induced cytotoxic oxidative stress. Here, we show that androgens increase the expression of p22(phox) and gp91(phox) subunits of NADPH oxidase (NOX) and ROS production by NOX2 and NOX4 in PC. Pre-radiation treatment of 22Rv1 human PC cells with NOX inhibitors sensitize the cells to radiation similarly to ADT, suggesting that their future usage may spare the need for adjuvant ADT in PC patients undergoing radiation.
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spelling pubmed-28343422010-03-29 Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase Lu, J P Monardo, L Bryskin, I Hou, Z F Trachtenberg, J Wilson, B C Pinthus, J H Prostate Cancer Prostatic Dis Original Articles Androgen deprivation therapy (ADT) facilitates the response of prostate cancer (PC) to radiation. Androgens have been shown to induce elevated basal levels of reactive oxygen species (ROS) in PC, leading to adaptation to radiation-induced cytotoxic oxidative stress. Here, we show that androgens increase the expression of p22(phox) and gp91(phox) subunits of NADPH oxidase (NOX) and ROS production by NOX2 and NOX4 in PC. Pre-radiation treatment of 22Rv1 human PC cells with NOX inhibitors sensitize the cells to radiation similarly to ADT, suggesting that their future usage may spare the need for adjuvant ADT in PC patients undergoing radiation. Nature Publishing Group 2009-06-23 2010-03 /pmc/articles/PMC2834342/ /pubmed/19546883 http://dx.doi.org/10.1038/pcan.2009.24 Text en Copyright 2010, Nature Publishing Group http://creativecommons.org/licenses/by-nc-sa/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Original Articles
Lu, J P
Monardo, L
Bryskin, I
Hou, Z F
Trachtenberg, J
Wilson, B C
Pinthus, J H
Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase
title Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase
title_full Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase
title_fullStr Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase
title_full_unstemmed Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase
title_short Androgens induce oxidative stress and radiation resistance in prostate cancer cells though NADPH oxidase
title_sort androgens induce oxidative stress and radiation resistance in prostate cancer cells though nadph oxidase
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834342/
https://www.ncbi.nlm.nih.gov/pubmed/19546883
http://dx.doi.org/10.1038/pcan.2009.24
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