Effect of domperidone on the QTc interval in premature infants

OBJECTIVE: To evaluate the effect of domperidone use on corrected QT interval in premature infants. STUDY DESIGN: A prospective study of premature infants receiving domperidone was included in this study. A baseline electrocardiogram was obtained just before and 3, 7 and 14 days after initiation of...

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Autores principales: Günlemez, A, Babaoğlu, A, Arısoy, A E, Türker, G, Gökalp, A S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834362/
https://www.ncbi.nlm.nih.gov/pubmed/19626027
http://dx.doi.org/10.1038/jp.2009.96
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author Günlemez, A
Babaoğlu, A
Arısoy, A E
Türker, G
Gökalp, A S
author_facet Günlemez, A
Babaoğlu, A
Arısoy, A E
Türker, G
Gökalp, A S
author_sort Günlemez, A
collection PubMed
description OBJECTIVE: To evaluate the effect of domperidone use on corrected QT interval in premature infants. STUDY DESIGN: A prospective study of premature infants receiving domperidone was included in this study. A baseline electrocardiogram was obtained just before and 3, 7 and 14 days after initiation of domperidone. Corrected QT was considered prolonged if it exceeded the upper limit for age. RESULT: A total of 40 premature infants were enrolled in this study. The mean birth weight of 1109±332 g, mean gestational age of 28.8±2.4 years and mean age at the onset of domperidone were 32.8±2 days. No difference in corrected QT interval was observed between just before and 3, 7 and 14 days after the start of the treatment. Two infants had corrected QT interval prolongation without any clinical side effect that resolved spontaneously. CONCLUSION: Our experience suggests that domperidone administered cautiously in modest doses does not result in arrhythmias or conduction defects in premature infants statistically. Additional data are needed to give optimal advice regarding the safety of domperidone treatment in premature infants.
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spelling pubmed-28343622010-03-29 Effect of domperidone on the QTc interval in premature infants Günlemez, A Babaoğlu, A Arısoy, A E Türker, G Gökalp, A S J Perinatol Original Article OBJECTIVE: To evaluate the effect of domperidone use on corrected QT interval in premature infants. STUDY DESIGN: A prospective study of premature infants receiving domperidone was included in this study. A baseline electrocardiogram was obtained just before and 3, 7 and 14 days after initiation of domperidone. Corrected QT was considered prolonged if it exceeded the upper limit for age. RESULT: A total of 40 premature infants were enrolled in this study. The mean birth weight of 1109±332 g, mean gestational age of 28.8±2.4 years and mean age at the onset of domperidone were 32.8±2 days. No difference in corrected QT interval was observed between just before and 3, 7 and 14 days after the start of the treatment. Two infants had corrected QT interval prolongation without any clinical side effect that resolved spontaneously. CONCLUSION: Our experience suggests that domperidone administered cautiously in modest doses does not result in arrhythmias or conduction defects in premature infants statistically. Additional data are needed to give optimal advice regarding the safety of domperidone treatment in premature infants. Nature Publishing Group 2010-01 2009-07-23 /pmc/articles/PMC2834362/ /pubmed/19626027 http://dx.doi.org/10.1038/jp.2009.96 Text en Copyright © 2010 Nature Publishing Group http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Original Article
Günlemez, A
Babaoğlu, A
Arısoy, A E
Türker, G
Gökalp, A S
Effect of domperidone on the QTc interval in premature infants
title Effect of domperidone on the QTc interval in premature infants
title_full Effect of domperidone on the QTc interval in premature infants
title_fullStr Effect of domperidone on the QTc interval in premature infants
title_full_unstemmed Effect of domperidone on the QTc interval in premature infants
title_short Effect of domperidone on the QTc interval in premature infants
title_sort effect of domperidone on the qtc interval in premature infants
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834362/
https://www.ncbi.nlm.nih.gov/pubmed/19626027
http://dx.doi.org/10.1038/jp.2009.96
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