Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer

We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive resp...

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Detalles Bibliográficos
Autores principales: Kamrava, M., Tsang, Kwong Y., Madan, R. A., Kaushal, A., Coleman, C. N., Gulley, J.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834955/
https://www.ncbi.nlm.nih.gov/pubmed/20224813
http://dx.doi.org/10.1155/2009/363914
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author Kamrava, M.
Tsang, Kwong Y.
Madan, R. A.
Kaushal, A.
Coleman, C. N.
Gulley, J.
author_facet Kamrava, M.
Tsang, Kwong Y.
Madan, R. A.
Kaushal, A.
Coleman, C. N.
Gulley, J.
author_sort Kamrava, M.
collection PubMed
description We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive response may be related to an improved antitumor immune response of the patient, increased immunogenicity of the tumor, or decreased activation of immune escape pathways. Further evaluation of therapeutic cancer vaccines in combination with radiation and hormonal therapy in the definitive management of prostate cancer is warranted.
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spelling pubmed-28349552010-03-11 Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer Kamrava, M. Tsang, Kwong Y. Madan, R. A. Kaushal, A. Coleman, C. N. Gulley, J. Clin Dev Immunol Case Report We describe a patient with node positive prostate cancer treated with radiation, androgen deprivation, and immunotherapy with long-term overall survival and PSA control. ELISPOT immunoassay studies demonstrated PSA specific T-cells prior to starting vaccine therapy suggesting that this positive response may be related to an improved antitumor immune response of the patient, increased immunogenicity of the tumor, or decreased activation of immune escape pathways. Further evaluation of therapeutic cancer vaccines in combination with radiation and hormonal therapy in the definitive management of prostate cancer is warranted. Hindawi Publishing Corporation 2009 2010-03-08 /pmc/articles/PMC2834955/ /pubmed/20224813 http://dx.doi.org/10.1155/2009/363914 Text en Copyright © 2009 National Cancer Institute, National Institutes of Health (NIH/NCI). https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kamrava, M.
Tsang, Kwong Y.
Madan, R. A.
Kaushal, A.
Coleman, C. N.
Gulley, J.
Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer
title Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer
title_full Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer
title_fullStr Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer
title_full_unstemmed Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer
title_short Long-Term Survival and PSA Control with Radiation and Immunotherapy for Node Positive Prostate Cancer
title_sort long-term survival and psa control with radiation and immunotherapy for node positive prostate cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834955/
https://www.ncbi.nlm.nih.gov/pubmed/20224813
http://dx.doi.org/10.1155/2009/363914
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