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Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience
Radiotherapy (RT) is our preferred modality for local palliation of metastatic soft tissue sarcoma (STS). A short and intense course of RT is usually needed for rapid palliation and local control of metastatic disease. Seventeen patients at a median age of 61 had symptomatic metastatic sarcoma and r...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834957/ https://www.ncbi.nlm.nih.gov/pubmed/20224682 http://dx.doi.org/10.1155/2010/927972 |
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author | Soyfer, Viacheslav Corn, Benjamin W. Kollender, Yehuda Tempelhoff, Haim Meller, Isaac Merimsky, Ofer |
author_facet | Soyfer, Viacheslav Corn, Benjamin W. Kollender, Yehuda Tempelhoff, Haim Meller, Isaac Merimsky, Ofer |
author_sort | Soyfer, Viacheslav |
collection | PubMed |
description | Radiotherapy (RT) is our preferred modality for local palliation of metastatic soft tissue sarcoma (STS). A short and intense course of RT is usually needed for rapid palliation and local control of metastatic disease. Seventeen patients at a median age of 61 had symptomatic metastatic sarcoma and required rapid palliation. The symptoms related to the metastases were either pain or discomfort. All patients were treated by a short and intensive course of administration: 39 Gy were given in 13 fractions of 3 Gy/day, 5 times a week. Median follow-up period was 25 weeks. The treatment was well tolerated. Acute side effects included grade one skin toxicity. No wound complications were noted among those undergoing surgery. Late side effects included skin pigmentation and induration of irradiated soft tissues. Durable pain control was achieved in 12 out 15 cases treated for gross metastases. Tumor progression was seen in the 3 other cases within a period of two to nine months. Among 5 lesions which were irradiated as an adjunctive treatment following resection, no local recurrence was observed. The results of this series, although limited in size, point to the safety and feasibility of hypofractionated RT for palliation of musculoskeletal metastases from sarcoma. |
format | Text |
id | pubmed-2834957 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28349572010-03-11 Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience Soyfer, Viacheslav Corn, Benjamin W. Kollender, Yehuda Tempelhoff, Haim Meller, Isaac Merimsky, Ofer Sarcoma Clinical Study Radiotherapy (RT) is our preferred modality for local palliation of metastatic soft tissue sarcoma (STS). A short and intense course of RT is usually needed for rapid palliation and local control of metastatic disease. Seventeen patients at a median age of 61 had symptomatic metastatic sarcoma and required rapid palliation. The symptoms related to the metastases were either pain or discomfort. All patients were treated by a short and intensive course of administration: 39 Gy were given in 13 fractions of 3 Gy/day, 5 times a week. Median follow-up period was 25 weeks. The treatment was well tolerated. Acute side effects included grade one skin toxicity. No wound complications were noted among those undergoing surgery. Late side effects included skin pigmentation and induration of irradiated soft tissues. Durable pain control was achieved in 12 out 15 cases treated for gross metastases. Tumor progression was seen in the 3 other cases within a period of two to nine months. Among 5 lesions which were irradiated as an adjunctive treatment following resection, no local recurrence was observed. The results of this series, although limited in size, point to the safety and feasibility of hypofractionated RT for palliation of musculoskeletal metastases from sarcoma. Hindawi Publishing Corporation 2010 2010-03-08 /pmc/articles/PMC2834957/ /pubmed/20224682 http://dx.doi.org/10.1155/2010/927972 Text en Copyright © 2010 Viacheslav Soyfer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Soyfer, Viacheslav Corn, Benjamin W. Kollender, Yehuda Tempelhoff, Haim Meller, Isaac Merimsky, Ofer Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience |
title | Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience |
title_full | Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience |
title_fullStr | Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience |
title_full_unstemmed | Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience |
title_short | Radiation Therapy for Palliation of Sarcoma Metastases: A Unique and Uniform Hypofractionation Experience |
title_sort | radiation therapy for palliation of sarcoma metastases: a unique and uniform hypofractionation experience |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834957/ https://www.ncbi.nlm.nih.gov/pubmed/20224682 http://dx.doi.org/10.1155/2010/927972 |
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