Cargando…

The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population

BACKGROUND: The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatolog...

Descripción completa

Detalles Bibliográficos
Autores principales: Alzamora, María Teresa, Forés, Rosa, Baena-Díez, José Miguel, Pera, Guillem, Toran, Pere, Sorribes, Marta, Vicheto, Marisa, Reina, María Dolores, Sancho, Amparo, Albaladejo, Carlos, Llussà, Judith
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835682/
https://www.ncbi.nlm.nih.gov/pubmed/20529387
http://dx.doi.org/10.1186/1471-2458-10-38
_version_ 1782178648747409408
author Alzamora, María Teresa
Forés, Rosa
Baena-Díez, José Miguel
Pera, Guillem
Toran, Pere
Sorribes, Marta
Vicheto, Marisa
Reina, María Dolores
Sancho, Amparo
Albaladejo, Carlos
Llussà, Judith
author_facet Alzamora, María Teresa
Forés, Rosa
Baena-Díez, José Miguel
Pera, Guillem
Toran, Pere
Sorribes, Marta
Vicheto, Marisa
Reina, María Dolores
Sancho, Amparo
Albaladejo, Carlos
Llussà, Judith
author_sort Alzamora, María Teresa
collection PubMed
description BACKGROUND: The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease). The aim of the study is to know the prevalence and associated risk factors of peripheral arterial disease in the general population. METHODS: We performed a cross-sectional, multicentre, population-based study in 3786 individuals >49 years, randomly selected in 28 primary care centres in Barcelona (Spain). Peripheral arterial disease was evaluated using the ankle-arm index. Values < 0.9 were considered as peripheral arterial disease. RESULTS: The prevalence (95% confidence interval) of peripheral arterial disease was 7.6% (6.7-8.4), (males 10.2% (9.2-11.2), females 5.3% (4.6-6.0); p < 0.001). Multivariate analysis showed the following risk factors: male sex [odds ratio (OR) 1.62; 95% confidence interval 1.01-2.59]; age OR 2.00 per 10 years (1.64-2.44); inability to perform physical activity [OR 1.77 (1.17-2.68) for mild limitation to OR 7.08 (2.61-19.16) for breathless performing any activity]; smoking [OR 2.19 (1.34-3.58) for former smokers and OR 3.83 (2.23-6.58) for current smokers]; hypertension OR 1.85 (1.29-2.65); diabetes OR 2.01 (1.42-2.83); previous cardiovascular disease OR 2.19 (1.52-3.15); hypercholesterolemia OR 1.55 (1.11-2.18); hypertriglyceridemia OR 1.55 (1.10-2.19). Body mass index ≥25 Kg/m(2 )OR 0.57 (0.38-0.87) and walking >7 hours/week OR 0.67 (0.49-0.94) were found as protector factors. CONCLUSIONS: The prevalence of peripheral arterial disease is low, higher in males and increases with age in both sexes. In addition to previously described risk factors we found a protector effect in physical exercise and overweight.
format Text
id pubmed-2835682
institution National Center for Biotechnology Information
language English
publishDate 2010
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-28356822010-03-10 The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population Alzamora, María Teresa Forés, Rosa Baena-Díez, José Miguel Pera, Guillem Toran, Pere Sorribes, Marta Vicheto, Marisa Reina, María Dolores Sancho, Amparo Albaladejo, Carlos Llussà, Judith BMC Public Health Research article BACKGROUND: The early diagnosis of atherosclerotic disease is essential for developing preventive strategies in populations at high risk and acting when the disease is still asymptomatic. A low ankle-arm index is a good marker of vascular events and may be diminished without presenting symptomatology (silent peripheral arterial disease). The aim of the study is to know the prevalence and associated risk factors of peripheral arterial disease in the general population. METHODS: We performed a cross-sectional, multicentre, population-based study in 3786 individuals >49 years, randomly selected in 28 primary care centres in Barcelona (Spain). Peripheral arterial disease was evaluated using the ankle-arm index. Values < 0.9 were considered as peripheral arterial disease. RESULTS: The prevalence (95% confidence interval) of peripheral arterial disease was 7.6% (6.7-8.4), (males 10.2% (9.2-11.2), females 5.3% (4.6-6.0); p < 0.001). Multivariate analysis showed the following risk factors: male sex [odds ratio (OR) 1.62; 95% confidence interval 1.01-2.59]; age OR 2.00 per 10 years (1.64-2.44); inability to perform physical activity [OR 1.77 (1.17-2.68) for mild limitation to OR 7.08 (2.61-19.16) for breathless performing any activity]; smoking [OR 2.19 (1.34-3.58) for former smokers and OR 3.83 (2.23-6.58) for current smokers]; hypertension OR 1.85 (1.29-2.65); diabetes OR 2.01 (1.42-2.83); previous cardiovascular disease OR 2.19 (1.52-3.15); hypercholesterolemia OR 1.55 (1.11-2.18); hypertriglyceridemia OR 1.55 (1.10-2.19). Body mass index ≥25 Kg/m(2 )OR 0.57 (0.38-0.87) and walking >7 hours/week OR 0.67 (0.49-0.94) were found as protector factors. CONCLUSIONS: The prevalence of peripheral arterial disease is low, higher in males and increases with age in both sexes. In addition to previously described risk factors we found a protector effect in physical exercise and overweight. BioMed Central 2010-01-27 /pmc/articles/PMC2835682/ /pubmed/20529387 http://dx.doi.org/10.1186/1471-2458-10-38 Text en Copyright ©2010 Alzamora et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research article
Alzamora, María Teresa
Forés, Rosa
Baena-Díez, José Miguel
Pera, Guillem
Toran, Pere
Sorribes, Marta
Vicheto, Marisa
Reina, María Dolores
Sancho, Amparo
Albaladejo, Carlos
Llussà, Judith
The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population
title The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population
title_full The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population
title_fullStr The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population
title_full_unstemmed The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population
title_short The Peripheral Arterial disease study (PERART/ARTPER): prevalence and risk factors in the general population
title_sort peripheral arterial disease study (perart/artper): prevalence and risk factors in the general population
topic Research article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835682/
https://www.ncbi.nlm.nih.gov/pubmed/20529387
http://dx.doi.org/10.1186/1471-2458-10-38
work_keys_str_mv AT alzamoramariateresa theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT foresrosa theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT baenadiezjosemiguel theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT peraguillem theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT toranpere theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT sorribesmarta theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT vichetomarisa theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT reinamariadolores theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT sanchoamparo theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT albaladejocarlos theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT llussajudith theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT theperipheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT alzamoramariateresa peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT foresrosa peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT baenadiezjosemiguel peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT peraguillem peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT toranpere peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT sorribesmarta peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT vichetomarisa peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT reinamariadolores peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT sanchoamparo peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT albaladejocarlos peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT llussajudith peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation
AT peripheralarterialdiseasestudyperartartperprevalenceandriskfactorsinthegeneralpopulation