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Molecular modeling of the reductase domain to elucidate the reaction mechanism of reduction of peptidyl thioester into its corresponding alcohol in non-ribosomal peptide synthetases

BACKGROUND: Nonribosomal peptide synthetases (NRPSs) are multienzymatic, multidomain megasynthases involved in the biosynthesis of pharmaceutically important nonribosomal peptides. The peptaibol synthetase from Trichoderma virens (TPS) is an important member of the NRPS family that exhibits antifung...

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Detalles Bibliográficos
Autores principales:	Manavalan, Balachandran, Murugapiran, Senthil K, Lee, Gwang, Choi, Sangdun
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2010
Materias:	Research article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835699/ https://www.ncbi.nlm.nih.gov/pubmed/20067617 http://dx.doi.org/10.1186/1472-6807-10-1

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