Histone deacetylase controls adult stem cell aging by balancing the expression of polycomb genes and jumonji domain containing 3

Aging is linked to loss of the self-renewal capacity of adult stem cells. Here, we observed that human multipotent stem cells (MSCs) underwent cellular senescence in vitro. Decreased expression of histone deacetylases (HDACs), followed by downregulation of polycomb group genes (PcGs), such as BMI1,...

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Detalles Bibliográficos
Autores principales: Jung, Ji-Won, Lee, Seunghee, Seo, Min-Soo, Park, Sang-Bum, Kurtz, Andreas, Kang, Soo-Kyung, Kang, Kyung-Sun
Formato: Texto
Lenguaje:English
Publicado: SP Birkhäuser Verlag Basel 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835723/
https://www.ncbi.nlm.nih.gov/pubmed/20049504
http://dx.doi.org/10.1007/s00018-009-0242-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835723/
https://www.ncbi.nlm.nih.gov/pubmed/20049504
http://dx.doi.org/10.1007/s00018-009-0242-9

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