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Timing is everything: the regulation of type III secretion
Type Three Secretion Systems (T3SSs) are essential virulence determinants of many Gram-negative bacteria. The T3SS is an injection device that can transfer bacterial virulence proteins directly into host cells. The apparatus is made up of a basal body that spans both bacterial membranes and an extra...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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SP Birkhäuser Verlag Basel
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835726/ https://www.ncbi.nlm.nih.gov/pubmed/20043184 http://dx.doi.org/10.1007/s00018-009-0230-0 |
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author | Deane, Janet E. Abrusci, Patrizia Johnson, Steven Lea, Susan M. |
author_facet | Deane, Janet E. Abrusci, Patrizia Johnson, Steven Lea, Susan M. |
author_sort | Deane, Janet E. |
collection | PubMed |
description | Type Three Secretion Systems (T3SSs) are essential virulence determinants of many Gram-negative bacteria. The T3SS is an injection device that can transfer bacterial virulence proteins directly into host cells. The apparatus is made up of a basal body that spans both bacterial membranes and an extracellular needle that possesses a channel that is thought to act as a conduit for protein secretion. Contact with a host-cell membrane triggers the insertion of a pore into the target membrane, and effectors are translocated through this pore into the host cell. To assemble a functional T3SS, specific substrates must be targeted to the apparatus in the correct order. Recently, there have been many developments in our structural and functional understanding of the proteins involved in the regulation of secretion. Here we review the current understanding of protein components of the system thought to be involved in switching between different stages of secretion. |
format | Text |
id | pubmed-2835726 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | SP Birkhäuser Verlag Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-28357262010-03-24 Timing is everything: the regulation of type III secretion Deane, Janet E. Abrusci, Patrizia Johnson, Steven Lea, Susan M. Cell Mol Life Sci Review Type Three Secretion Systems (T3SSs) are essential virulence determinants of many Gram-negative bacteria. The T3SS is an injection device that can transfer bacterial virulence proteins directly into host cells. The apparatus is made up of a basal body that spans both bacterial membranes and an extracellular needle that possesses a channel that is thought to act as a conduit for protein secretion. Contact with a host-cell membrane triggers the insertion of a pore into the target membrane, and effectors are translocated through this pore into the host cell. To assemble a functional T3SS, specific substrates must be targeted to the apparatus in the correct order. Recently, there have been many developments in our structural and functional understanding of the proteins involved in the regulation of secretion. Here we review the current understanding of protein components of the system thought to be involved in switching between different stages of secretion. SP Birkhäuser Verlag Basel 2009-12-31 2010 /pmc/articles/PMC2835726/ /pubmed/20043184 http://dx.doi.org/10.1007/s00018-009-0230-0 Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Deane, Janet E. Abrusci, Patrizia Johnson, Steven Lea, Susan M. Timing is everything: the regulation of type III secretion |
title | Timing is everything: the regulation of type III secretion |
title_full | Timing is everything: the regulation of type III secretion |
title_fullStr | Timing is everything: the regulation of type III secretion |
title_full_unstemmed | Timing is everything: the regulation of type III secretion |
title_short | Timing is everything: the regulation of type III secretion |
title_sort | timing is everything: the regulation of type iii secretion |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835726/ https://www.ncbi.nlm.nih.gov/pubmed/20043184 http://dx.doi.org/10.1007/s00018-009-0230-0 |
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