ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

Telomere shortening caused by incomplete DNA replication is balanced by telomerase-mediated telomere extension, with evidence indicating that the shortest telomeres are preferred substrates in primary cells. Critically short telomeres are detected by the cellular DNA damage response (DDR) system. In...

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Detalles Bibliográficos
Autores principales: McNees, Carolyn J., Tejera, Agueda M., Martínez, Paula, Murga, Matilde, Mulero, Francisca, Fernandez-Capetillo, Oscar, Blasco, Maria A.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2010
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835929/
https://www.ncbi.nlm.nih.gov/pubmed/20212315
http://dx.doi.org/10.1083/jcb.200908136

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835929/
https://www.ncbi.nlm.nih.gov/pubmed/20212315
http://dx.doi.org/10.1083/jcb.200908136

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