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ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase
Telomere shortening caused by incomplete DNA replication is balanced by telomerase-mediated telomere extension, with evidence indicating that the shortest telomeres are preferred substrates in primary cells. Critically short telomeres are detected by the cellular DNA damage response (DDR) system. In...
| Autores principales: | , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835929/ https://www.ncbi.nlm.nih.gov/pubmed/20212315 http://dx.doi.org/10.1083/jcb.200908136 |