The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds

The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA. In this study, we show that common and rare cervical precancer lesions, including tho...

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Autores principales: Ndisang, Daniel, Lorenzato, Felipe, Sindos, Michael, Khan, Ashfaq, Singer, Albert, Latchman, David S.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836136/
https://www.ncbi.nlm.nih.gov/pubmed/20224757
http://dx.doi.org/10.1155/2009/359457
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author Ndisang, Daniel
Lorenzato, Felipe
Sindos, Michael
Khan, Ashfaq
Singer, Albert
Latchman, David S.
author_facet Ndisang, Daniel
Lorenzato, Felipe
Sindos, Michael
Khan, Ashfaq
Singer, Albert
Latchman, David S.
author_sort Ndisang, Daniel
collection PubMed
description The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA. In this study, we show that common and rare cervical precancer lesions, including those of adenocarcinoma (AC), which are usually difficult to diagnose using classical procedures, also expressed high levels of Brn-3a and can be diagnosed by measuring the levels of Brn-3a and E6 mRNAs.
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spelling pubmed-28361362010-03-11 The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds Ndisang, Daniel Lorenzato, Felipe Sindos, Michael Khan, Ashfaq Singer, Albert Latchman, David S. Obstet Gynecol Int Research Article The cellular transactivator Brn-3a has previously been shown to be expressed at elevated levels in the cervix of women with squamous cell carcinoma of the cervix (SCC) and to activate the expression of HPV E6 mRNA. In this study, we show that common and rare cervical precancer lesions, including those of adenocarcinoma (AC), which are usually difficult to diagnose using classical procedures, also expressed high levels of Brn-3a and can be diagnosed by measuring the levels of Brn-3a and E6 mRNAs. Hindawi Publishing Corporation 2009 2010-03-09 /pmc/articles/PMC2836136/ /pubmed/20224757 http://dx.doi.org/10.1155/2009/359457 Text en Copyright © 2009 Daniel Ndisang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ndisang, Daniel
Lorenzato, Felipe
Sindos, Michael
Khan, Ashfaq
Singer, Albert
Latchman, David S.
The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds
title The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds
title_full The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds
title_fullStr The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds
title_full_unstemmed The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds
title_short The HPV Cellular Transactivator Brn-3a Can Be Used to Predict Cervical Adenocarcinoma and Squamous Carcinoma Precancer Lesions in the Developed and Developing Worlds
title_sort hpv cellular transactivator brn-3a can be used to predict cervical adenocarcinoma and squamous carcinoma precancer lesions in the developed and developing worlds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836136/
https://www.ncbi.nlm.nih.gov/pubmed/20224757
http://dx.doi.org/10.1155/2009/359457
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