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Heterodimeric DNA methyltransferases as a platform for creating designer zinc finger methyltransferases for targeted DNA methylation in cells

The ability to target methylation to specific genomic sites would further the study of DNA methylation’s biological role and potentially offer a tool for silencing gene expression and for treating diseases involving abnormal hypomethylation. The end-to-end fusion of DNA methyltransferases to zinc fi...

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Detalles Bibliográficos
Autores principales:	Meister, Glenna E., Chandrasegaran, Srinivasan, Ostermeier, Marc
Formato:	Texto
Lenguaje:	English
Publicado:	Oxford University Press 2010
Materias:	Synthetic Biology and Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836561/ https://www.ncbi.nlm.nih.gov/pubmed/20007601 http://dx.doi.org/10.1093/nar/gkp1126

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