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Morphological Changes of Gingiva in Streptozotocin Diabetic Rats

Gingivitis and periodontitis are chronic bacterial diseases of the underlying and surrounding tooth tissues. Diabetes mellitus is responsible for tooth deprivation both by decay and periodontal disease. The streptozotocin-induced diabetes results in a diabetic status in experimental animals similar...

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Autores principales: Tesseromatis, C., Kotsiou, A., Parara, H., Vairaktaris, E., Tsamouri, M.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836915/
https://www.ncbi.nlm.nih.gov/pubmed/20339569
http://dx.doi.org/10.1155/2009/725628
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author Tesseromatis, C.
Kotsiou, A.
Parara, H.
Vairaktaris, E.
Tsamouri, M.
author_facet Tesseromatis, C.
Kotsiou, A.
Parara, H.
Vairaktaris, E.
Tsamouri, M.
author_sort Tesseromatis, C.
collection PubMed
description Gingivitis and periodontitis are chronic bacterial diseases of the underlying and surrounding tooth tissues. Diabetes mellitus is responsible for tooth deprivation both by decay and periodontal disease. The streptozotocin-induced diabetes results in a diabetic status in experimental animals similar to that observed in diabetes patients. The aim of the study was to investigate the relationship between the gingival lesions and the microangiopathy changes in streptozotocin-induced diabetes mellitus. Forty male Wistar rats were divided into two groups (control and experimental). Diabetes mellitus was induced by 45 mg/kg IV streptozotocin. The histological investigation of the marginal gingival and the relevant gingival papilla showed inflammation of the lamina propria and the squamous epithelium as well as marked thickness of the arteriole in the diabetic group, but no changes were observed in the control group. The results suggested a probable application of a routine gingival histological investigation in diabetic patients in order to control the progress of disease complications. It may be concluded that histological gingival investigation can be used as a routine assay for the control of the diabetic disease and prevention of its complications.
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spelling pubmed-28369152010-03-25 Morphological Changes of Gingiva in Streptozotocin Diabetic Rats Tesseromatis, C. Kotsiou, A. Parara, H. Vairaktaris, E. Tsamouri, M. Int J Dent Research Article Gingivitis and periodontitis are chronic bacterial diseases of the underlying and surrounding tooth tissues. Diabetes mellitus is responsible for tooth deprivation both by decay and periodontal disease. The streptozotocin-induced diabetes results in a diabetic status in experimental animals similar to that observed in diabetes patients. The aim of the study was to investigate the relationship between the gingival lesions and the microangiopathy changes in streptozotocin-induced diabetes mellitus. Forty male Wistar rats were divided into two groups (control and experimental). Diabetes mellitus was induced by 45 mg/kg IV streptozotocin. The histological investigation of the marginal gingival and the relevant gingival papilla showed inflammation of the lamina propria and the squamous epithelium as well as marked thickness of the arteriole in the diabetic group, but no changes were observed in the control group. The results suggested a probable application of a routine gingival histological investigation in diabetic patients in order to control the progress of disease complications. It may be concluded that histological gingival investigation can be used as a routine assay for the control of the diabetic disease and prevention of its complications. Hindawi Publishing Corporation 2009 2009-01-27 /pmc/articles/PMC2836915/ /pubmed/20339569 http://dx.doi.org/10.1155/2009/725628 Text en Copyright © 2009 C. Tesseromatis et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Tesseromatis, C.
Kotsiou, A.
Parara, H.
Vairaktaris, E.
Tsamouri, M.
Morphological Changes of Gingiva in Streptozotocin Diabetic Rats
title Morphological Changes of Gingiva in Streptozotocin Diabetic Rats
title_full Morphological Changes of Gingiva in Streptozotocin Diabetic Rats
title_fullStr Morphological Changes of Gingiva in Streptozotocin Diabetic Rats
title_full_unstemmed Morphological Changes of Gingiva in Streptozotocin Diabetic Rats
title_short Morphological Changes of Gingiva in Streptozotocin Diabetic Rats
title_sort morphological changes of gingiva in streptozotocin diabetic rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836915/
https://www.ncbi.nlm.nih.gov/pubmed/20339569
http://dx.doi.org/10.1155/2009/725628
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