Cargando…

Poleward Transport of TPX2 in the Mammalian Mitotic Spindle Requires Dynein, Eg5, and Microtubule Flux

TPX2 is a Ran-regulated spindle assembly factor that is required for kinetochore fiber formation and activation of the mitotic kinase Aurora A. TPX2 is enriched near spindle poles and is required near kinetochores, suggesting that it undergoes dynamic relocalization throughout mitosis. Using photoac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Nan, Tulu, U. S., Ferenz, Nick P., Fagerstrom, Carey, Wilde, Andrew, Wadsworth, Patricia
Formato:	Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2010
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836978/ https://www.ncbi.nlm.nih.gov/pubmed/20110350 http://dx.doi.org/10.1091/mbc.E09-07-0601

Ejemplares similares

Dynamic reorganization of Eg5 in the mammalian spindle throughout mitosis requires dynein and TPX2
por: Gable, Alyssa, et al.
Publicado: (2012)

TPX2 regulates the localization and activity of Eg5 in the mammalian mitotic spindle
por: Ma, Nan, et al.
Publicado: (2011)

Poleward microtubule flux mitotic spindles assembled in vitro
Publicado: (1991)

Polewards microtubule flux in the mitotic spindle: evidence from photoactivation of fluorescence
Publicado: (1989)

The kinesin Eg5 drives poleward microtubule flux in Xenopus laevis egg extract spindles
por: Miyamoto, David T., et al.
Publicado: (2004)

Poleward transport of Eg5 by dynein–dynactin in Xenopus laevis egg extract spindles
por: Uteng, Marianne, et al.
Publicado: (2008)

Reorganization of the microtubule array in prophase/prometaphase requires cytoplasmic dynein-dependent microtubule transport
por: Rusan, Nasser M., et al.
Publicado: (2002)

TPX2 phosphorylation maintains metaphase spindle length by regulating microtubule flux
por: Fu, Jingyan, et al.
Publicado: (2015)

Anaphase A Chromosome Movement and Poleward Spindle Microtubule Flux Occur At Similar Rates in Xenopus Extract Spindles
por: Desai, Arshad, et al.
Publicado: (1998)

The Kinesin-Related Protein, Hset, Opposes the Activity of Eg5 and Cross-Links Microtubules in the Mammalian Mitotic Spindle
por: Mountain, Vicki, et al.
Publicado: (1999)

Cytoplasmic dynein plays a role in mammalian mitotic spindle formation
Publicado: (1993)

Microtubule-dependent path to the cell cortex for cytoplasmic dynein in mitotic spindle orientation
por: Markus, Steven M., et al.
Publicado: (2011)

Microtubules Orient the Mitotic Spindle in Yeast through Dynein-dependent Interactions with the Cell Cortex
por: Carminati, Janet L., et al.
Publicado: (1997)

TPX2 is a drag on Eg5
por: Leslie, Mitch
Publicado: (2011)

Cytoskeletal architecture of isolated mitotic spindle with special reference to microtubule-associated proteins and cytoplasmic dynein
Publicado: (1985)

Kinesin 5–independent poleward flux of kinetochore microtubules in PtK1 cells
por: Cameron, Lisa A., et al.
Publicado: (2006)

Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit
por: Naso, Francesco D., et al.
Publicado: (2020)

HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors
por: Fang, Chieh-Ting, et al.
Publicado: (2020)

Decoration of spindle microtubules with Dynein: evidence for uniform polarity
Publicado: (1981)

ULTRASTRUCTURAL ANALYSIS OF MITOTIC SPINDLE ELONGATION IN MAMMALIAN CELLS IN VITRO : Direct Microtubule Counts
por: Brinkley, B. R., et al.
Publicado: (1971)

Mitotic control of kinetochore-associated dynein and spindle orientation by human Spindly
por: Chan, Ying Wai, et al.
Publicado: (2009)

Patronin mediates a switch from kinesin-13–dependent poleward flux to anaphase B spindle elongation
por: Wang, Haifeng, et al.
Publicado: (2013)

CtIP Regulates Mitotic Spindle Assembly by Modulating the TPX2-Aurora A Signaling Axis
por: Oh, Wonkyung, et al.
Publicado: (2022)

Spatial and Temporal Scaling of Microtubules and Mitotic Spindles
por: Lacroix, Benjamin, et al.
Publicado: (2022)

Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics
por: Mann, Barbara J., et al.
Publicado: (2017)

Kinetochores are transported poleward along a single astral microtubule during chromosome attachment to the spindle in newt lung cells
Publicado: (1990)

Two Kinesin-14A Motors Oligomerize to Drive Poleward Microtubule Convergence for Acentrosomal Spindle Morphogenesis in Arabidopsis thaliana
por: Hotta, Takashi, et al.
Publicado: (2022)

Motoring to the Finish: Kinesin and Dynein Work Together to Orient the Yeast Mitotic Spindle
por: Stearns, Tim
Publicado: (1997)

The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation
por: Mahale, Sagar, et al.
Publicado: (2016)

Clustering of cortical dynein regulates the mechanics of spindle orientation in human mitotic cells
por: Anjur-Dietrich, Maya I., et al.
Publicado: (2023)

PP6 regulation of Aurora A–TPX2 limits NDC80 phosphorylation and mitotic spindle size
por: Sobajima, Tomoaki, et al.
Publicado: (2023)

Microtubule pivoting enables mitotic spindle assembly in S. cerevisiae
por: Fong, Kimberly K., et al.
Publicado: (2021)

Probing Spindle Assembly Mechanisms with Monastrol, a Small Molecule Inhibitor of the Mitotic Kinesin, Eg5
por: Kapoor, Tarun M., et al.
Publicado: (2000)

Poleward force at the kinetochore in metaphase depends on the number of kinetochore microtubules
Publicado: (1990)

Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning
por: Gusnowski, Eva M., et al.
Publicado: (2011)

Astral microtubules control redistribution of dynein at the cell cortex to facilitate spindle positioning
por: Tame, Mihoko A, et al.
Publicado: (2014)

Studies of a microtubule-associated protein using a monoclonal antibody elicited against mammalian mitotic spindles
Publicado: (1984)

The mitotic spindle is chiral due to torques within microtubule bundles
por: Novak, Maja, et al.
Publicado: (2018)

Phosphorylation by Cdk1 Increases the Binding of Eg5 to Microtubules In Vitro and in Xenopus Egg Extract Spindles
por: Cahu, Julie, et al.
Publicado: (2008)

Regional variation of microtubule flux reveals microtubule organization in the metaphase meiotic spindle
por: Yang, Ge, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_u96k51na6lvlqhedm7b6vd5775