Transcriptional changes in response to X chromosome dosage in the mouse: implications for X inactivation and the molecular basis of Turner Syndrome

BACKGROUND: X monosomic mice (39,XO) have a remarkably mild phenotype when compared to women with Turner syndrome (45,XO). The generally accepted hypothesis to explain this discrepancy is that the number of genes on the mouse X chromosome which escape X inactivation, and thus are expressed at higher...

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Detalles Bibliográficos
Autores principales: Lopes, Alexandra M, Burgoyne, Paul S, Ojarikre, Andrew, Bauer, Julien, Sargent, Carole A, Amorim, António, Affara, Nabeel A
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837040/
https://www.ncbi.nlm.nih.gov/pubmed/20122165
http://dx.doi.org/10.1186/1471-2164-11-82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837040/
https://www.ncbi.nlm.nih.gov/pubmed/20122165
http://dx.doi.org/10.1186/1471-2164-11-82

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