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The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
One influential account asserts that the anterior temporal lobe (ATL) is a domain-general hub for semantic memory. Other evidence indicates it is part of a domain-specific social cognition system. Arbitrating these accounts using functional magnetic resonance imaging has previously been difficult be...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837089/ https://www.ncbi.nlm.nih.gov/pubmed/19620621 http://dx.doi.org/10.1093/cercor/bhp149 |
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author | Simmons, W. Kyle Reddish, Mark Bellgowan, Patrick S. F. Martin, Alex |
author_facet | Simmons, W. Kyle Reddish, Mark Bellgowan, Patrick S. F. Martin, Alex |
author_sort | Simmons, W. Kyle |
collection | PubMed |
description | One influential account asserts that the anterior temporal lobe (ATL) is a domain-general hub for semantic memory. Other evidence indicates it is part of a domain-specific social cognition system. Arbitrating these accounts using functional magnetic resonance imaging has previously been difficult because of magnetic susceptibility artifacts in the region. The present study used parameters optimized for imaging the ATL, and had subjects encode facts about unfamiliar people, buildings, and hammers. Using both conjunction and region of interest analyses, person-selective responses were observed in both the left and right ATL. Neither building-selective, hammer-selective nor domain-general responses were observed in the ATLs, although they were observed in other brain regions. These findings were supported by “resting-state” functional connectivity analyses using independent datasets from the same subjects. Person-selective ATL clusters were functionally connected with the brain's wider social cognition network. Rather than serving as a domain-general semantic hub, the ATLs work in unison with the social cognition system to support learning facts about others. |
format | Text |
id | pubmed-2837089 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-28370892010-03-12 The Selectivity and Functional Connectivity of the Anterior Temporal Lobes Simmons, W. Kyle Reddish, Mark Bellgowan, Patrick S. F. Martin, Alex Cereb Cortex Articles One influential account asserts that the anterior temporal lobe (ATL) is a domain-general hub for semantic memory. Other evidence indicates it is part of a domain-specific social cognition system. Arbitrating these accounts using functional magnetic resonance imaging has previously been difficult because of magnetic susceptibility artifacts in the region. The present study used parameters optimized for imaging the ATL, and had subjects encode facts about unfamiliar people, buildings, and hammers. Using both conjunction and region of interest analyses, person-selective responses were observed in both the left and right ATL. Neither building-selective, hammer-selective nor domain-general responses were observed in the ATLs, although they were observed in other brain regions. These findings were supported by “resting-state” functional connectivity analyses using independent datasets from the same subjects. Person-selective ATL clusters were functionally connected with the brain's wider social cognition network. Rather than serving as a domain-general semantic hub, the ATLs work in unison with the social cognition system to support learning facts about others. Oxford University Press 2010-04 2009-07-20 /pmc/articles/PMC2837089/ /pubmed/19620621 http://dx.doi.org/10.1093/cercor/bhp149 Text en Published by Oxford University Press 2009. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Articles Simmons, W. Kyle Reddish, Mark Bellgowan, Patrick S. F. Martin, Alex The Selectivity and Functional Connectivity of the Anterior Temporal Lobes |
title | The Selectivity and Functional Connectivity of the Anterior Temporal Lobes |
title_full | The Selectivity and Functional Connectivity of the Anterior Temporal Lobes |
title_fullStr | The Selectivity and Functional Connectivity of the Anterior Temporal Lobes |
title_full_unstemmed | The Selectivity and Functional Connectivity of the Anterior Temporal Lobes |
title_short | The Selectivity and Functional Connectivity of the Anterior Temporal Lobes |
title_sort | selectivity and functional connectivity of the anterior temporal lobes |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837089/ https://www.ncbi.nlm.nih.gov/pubmed/19620621 http://dx.doi.org/10.1093/cercor/bhp149 |
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