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The Selectivity and Functional Connectivity of the Anterior Temporal Lobes

One influential account asserts that the anterior temporal lobe (ATL) is a domain-general hub for semantic memory. Other evidence indicates it is part of a domain-specific social cognition system. Arbitrating these accounts using functional magnetic resonance imaging has previously been difficult be...

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Autores principales: Simmons, W. Kyle, Reddish, Mark, Bellgowan, Patrick S. F., Martin, Alex
Formato: Texto
Lenguaje:English
Publicado: Oxford University Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837089/
https://www.ncbi.nlm.nih.gov/pubmed/19620621
http://dx.doi.org/10.1093/cercor/bhp149
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author Simmons, W. Kyle
Reddish, Mark
Bellgowan, Patrick S. F.
Martin, Alex
author_facet Simmons, W. Kyle
Reddish, Mark
Bellgowan, Patrick S. F.
Martin, Alex
author_sort Simmons, W. Kyle
collection PubMed
description One influential account asserts that the anterior temporal lobe (ATL) is a domain-general hub for semantic memory. Other evidence indicates it is part of a domain-specific social cognition system. Arbitrating these accounts using functional magnetic resonance imaging has previously been difficult because of magnetic susceptibility artifacts in the region. The present study used parameters optimized for imaging the ATL, and had subjects encode facts about unfamiliar people, buildings, and hammers. Using both conjunction and region of interest analyses, person-selective responses were observed in both the left and right ATL. Neither building-selective, hammer-selective nor domain-general responses were observed in the ATLs, although they were observed in other brain regions. These findings were supported by “resting-state” functional connectivity analyses using independent datasets from the same subjects. Person-selective ATL clusters were functionally connected with the brain's wider social cognition network. Rather than serving as a domain-general semantic hub, the ATLs work in unison with the social cognition system to support learning facts about others.
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spelling pubmed-28370892010-03-12 The Selectivity and Functional Connectivity of the Anterior Temporal Lobes Simmons, W. Kyle Reddish, Mark Bellgowan, Patrick S. F. Martin, Alex Cereb Cortex Articles One influential account asserts that the anterior temporal lobe (ATL) is a domain-general hub for semantic memory. Other evidence indicates it is part of a domain-specific social cognition system. Arbitrating these accounts using functional magnetic resonance imaging has previously been difficult because of magnetic susceptibility artifacts in the region. The present study used parameters optimized for imaging the ATL, and had subjects encode facts about unfamiliar people, buildings, and hammers. Using both conjunction and region of interest analyses, person-selective responses were observed in both the left and right ATL. Neither building-selective, hammer-selective nor domain-general responses were observed in the ATLs, although they were observed in other brain regions. These findings were supported by “resting-state” functional connectivity analyses using independent datasets from the same subjects. Person-selective ATL clusters were functionally connected with the brain's wider social cognition network. Rather than serving as a domain-general semantic hub, the ATLs work in unison with the social cognition system to support learning facts about others. Oxford University Press 2010-04 2009-07-20 /pmc/articles/PMC2837089/ /pubmed/19620621 http://dx.doi.org/10.1093/cercor/bhp149 Text en Published by Oxford University Press 2009. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/uk/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Articles
Simmons, W. Kyle
Reddish, Mark
Bellgowan, Patrick S. F.
Martin, Alex
The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
title The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
title_full The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
title_fullStr The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
title_full_unstemmed The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
title_short The Selectivity and Functional Connectivity of the Anterior Temporal Lobes
title_sort selectivity and functional connectivity of the anterior temporal lobes
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837089/
https://www.ncbi.nlm.nih.gov/pubmed/19620621
http://dx.doi.org/10.1093/cercor/bhp149
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