Local IGF-1 isoform protects cardiomyocytes from hypertrophic and oxidative stresses via SirT1 activity

Oxidative and hypertrophic stresses contribute to the pathogenesis of heart failure. Insulin-like growth factor-1 (IGF-1) is a peptide hormone with a complex post-transcriptional regulation, generating distinct isoforms. Locally acting IGF-1 isoform (mIGF-1) helps the heart to recover from toxic inj...

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Detalles Bibliográficos
Autores principales: Vinciguerra, Manlio, Santini, Maria Paola, Claycomb, William C., Ladurner, Andreas G., Rosenthal, Nadia
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837204/
https://www.ncbi.nlm.nih.gov/pubmed/20228935

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837204/
https://www.ncbi.nlm.nih.gov/pubmed/20228935

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