Aging: Dial M for Mitochondria

A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can p...

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Detalles Bibliográficos
Autores principales: Hur, Jae H., Cho, Jaehyoung, Walker, David W.
Formato: Texto
Lenguaje:English
Publicado: Impact Journals LLC 2010
Materias:
Research Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837206/
https://www.ncbi.nlm.nih.gov/pubmed/20228940
Descripción
Sumario:A major goal of aging research is to identify interventions that prolong lifespan in distantly related organisms. In recent years, genetic studies in both nematodes and rodents have reported that moderate inactivation of genes important for mitochondrial electron transport chain (ETC) function can promote longevity. We performed an RNAi screen to probe the role of ETC components in modulating lifespan in the fruit flyDrosophila melanogaster. In this Research Perspective, we discuss our findings and how they may relate to similar studies in worms and mice.

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