Cargando…

Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor

BACKGROUND AND AIMS: Treatment of colorectal adenomas with selective cyclooxygenase-2 inhibitors can contribute to the chemoprevention of colorectal cancer (CRC), but the molecular background of their effect is not fully understood. We analysed the gene expression modulatory effect of N-(2-cyclohexy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Galamb, O, Spisák, S, Sipos, F, Tóth, K, Solymosi, N, Wichmann, B, Krenács, T, Valcz, G, Tulassay, Z, Molnár, B
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2010
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837560/ https://www.ncbi.nlm.nih.gov/pubmed/20087348 http://dx.doi.org/10.1038/sj.bjc.6605515

Ejemplares similares

Potential Biomarkers of Colorectal Adenoma–Dysplasia–Carcinoma Progression: mRNA Expression Profiling and In Situ Protein Detection on TMAs Reveal 15 Sequentially Upregulated and 2 Downregulated Genes
por: Galamb, Orsolya, et al.
Publicado: (2009)

Applicability of Antibody and mRNA Expression Microarrays for Identifying Diagnostic and Progression Markers of Early and Late Stage Colorectal Cancer
por: Spisák, Sándor, et al.
Publicado: (2010)

Dysplasia-Carcinoma Transition Specific Transcripts in Colonic Biopsy Samples
por: Galamb, Orsolya, et al.
Publicado: (2012)

Sporadic Colorectal Cancer Development Shows Rejuvenescence Regarding Epithelial Proliferation and Apoptosis
por: Leiszter, Katalin, et al.
Publicado: (2013)

Promoter Hypermethylation-Related Reduced Somatostatin Production Promotes Uncontrolled Cell Proliferation in Colorectal Cancer
por: Leiszter, Katalin, et al.
Publicado: (2015)

DNA hypermethylation and decreased mRNA expression of MAL, PRIMA1, PTGDR and SFRP1 in colorectal adenoma and cancer
por: Kalmár, Alexandra, et al.
Publicado: (2015)

Inflammation, Adenoma and Cancer: Objective Classification of Colon Biopsy Specimens with Gene Expression Signature
por: Galamb, Orsolya, et al.
Publicado: (2008)

Colorectal adenoma and carcinoma specific miRNA profiles in biopsy and their expression in plasma specimens
por: Nagy, Zsófia Brigitta, et al.
Publicado: (2017)

Peripheral Blood Based Discrimination of Ulcerative Colitis and Crohn’s Disease from Non-IBD Colitis by Genome-Wide Gene Expression Profiling
por: Sipos, Ferenc, et al.
Publicado: (2011)

Myofibroblast-Derived SFRP1 as Potential Inhibitor of Colorectal Carcinoma Field Effect
por: Valcz, Gábor, et al.
Publicado: (2014)

Aging related methylation influences the gene expression of key control genes in colorectal cancer and adenoma
por: Galamb, Orsolya, et al.
Publicado: (2016)

Genome-wide expression profiling in colorectal cancer focusing on lncRNAs in the adenoma-carcinoma transition
por: Kalmár, Alexandra, et al.
Publicado: (2019)

Comprehensive DNA Methylation Analysis Reveals a Common Ten-Gene Methylation Signature in Colorectal Adenomas and Carcinomas
por: Patai, Árpád V., et al.
Publicado: (2015)

Genome-Wide Screening of Genes Regulated by DNA Methylation in Colon Cancer Development
por: Spisák, Sándor, et al.
Publicado: (2012)

The COX-2-Selective Antagonist (NS-398) Inhibits Choroidal Neovascularization and Subretinal Fibrosis
por: Zhang, Ruoshuang, et al.
Publicado: (2016)

Small extracellular vesicle DNA-mediated horizontal gene transfer as a driving force for tumor evolution: Facts and riddles
por: Valcz, Gábor, et al.
Publicado: (2022)

Biological effects of selective COX-2 inhibitor NS398 on human glioblastoma cell lines
por: Palumbo, Paola, et al.
Publicado: (2020)

Gene-expression analysis of a colorectal cancer-specific discriminatory transcript set on formalin-fixed, paraffin-embedded (FFPE) tissue samples
por: Kalmár, Alexandra, et al.
Publicado: (2015)

Aberrant septin 9 DNA methylation in colorectal cancer is restricted to a single CpG island
por: Wasserkort, Reinhold, et al.
Publicado: (2013)

Complete Genes May Pass from Food to Human Blood
por: Spisák, Sándor, et al.
Publicado: (2013)

Perspective: bidirectional exosomal transport between cancer stem cells and their fibroblast-rich microenvironment during metastasis formation
por: Valcz, Gábor, et al.
Publicado: (2018)

Detection of Methylated Septin 9 in Tissue and Plasma of Colorectal Patients with Neoplasia and the Relationship to the Amount of Circulating Cell-Free DNA
por: Tóth, Kinga, et al.
Publicado: (2014)

COX2 genetic variation, NSAIDs, and advanced prostate cancer risk
por: Cheng, I, et al.
Publicado: (2007)

The Notch pathway in ovarian carcinomas and adenomas
por: Hopfer, O, et al.
Publicado: (2005)

Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma
por: Ali, I U, et al.
Publicado: (2005)

Association of Self-DNA Mediated TLR9-Related Gene, DNA Methyltransferase, and Cytokeratin Protein Expression Alterations in HT29-Cells to DNA Fragment Length and Methylation Status
por: Fűri, István, et al.
Publicado: (2013)

Wnt signalling in adenomas of familial adenomatous polyposis patients
por: Caldwell, G M, et al.
Publicado: (2010)

Polymorphisms in prostaglandin synthase 2/cyclooxygenase 2 (PTGS2/COX2) and risk of colorectal cancer
por: Cox, D G, et al.
Publicado: (2004)

MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression
por: Diosdado, B, et al.
Publicado: (2009)

The Wnt antagonist sFRP1 is downregulated in premalignant large bowel adenomas
por: Caldwell, G M, et al.
Publicado: (2006)

Thymidylate synthase polymorphisms, folate and B-vitamin intake, and risk of colorectal adenoma
por: Hubner, R A, et al.
Publicado: (2007)

En bloc release of MVB-like small extracellular vesicle clusters by colorectal carcinoma cells
por: Valcz, Gábor, et al.
Publicado: (2019)

Cyclin D1 A870G polymorphism and the risk of colorectal cancer and adenoma
por: Schernhammer, E S, et al.
Publicado: (2006)

DNA hypermethylation in the normal colonic mucosa of patients with colorectal cancer
por: Kawakami, K, et al.
Publicado: (2006)

Gene promoter and exon DNA methylation changes in colon cancer development – mRNA expression and tumor mutation alterations
por: Molnár, Béla, et al.
Publicado: (2018)

Increased NF-κB DNA binding but not transcriptional activity during apoptosis induced by the COX-2-selective inhibitor NS-398 in colorectal carcinoma cells
por: Smartt, H J M, et al.
Publicado: (2003)

B-RAF mutation and accumulated gene methylation in aberrant crypt foci (ACF), sessile serrated adenoma/polyp (SSA/P) and cancer in SSA/P
por: Inoue, A, et al.
Publicado: (2015)

A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas
por: Dom, G, et al.
Publicado: (2012)

Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer
por: Chang-Claude, J, et al.
Publicado: (2009)

Inhibition of cyclooxygenase-2 by NS398 attenuates noise-induced hearing loss in mice
por: Sun, Yu, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_dbepa2mpktavc4chr76hio2pgp