TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion

Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. T...

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Detalles Bibliográficos
Autores principales: Wu, Y, Zhou, B P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837572/
https://www.ncbi.nlm.nih.gov/pubmed/20087353
http://dx.doi.org/10.1038/sj.bjc.6605530
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author Wu, Y
Zhou, B P
author_facet Wu, Y
Zhou, B P
author_sort Wu, Y
collection PubMed
description Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-κB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment.
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spelling pubmed-28375722011-02-16 TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion Wu, Y Zhou, B P Br J Cancer Minireview Tumour necrosis factor-alpha (TNF-α) is an important inflammatory factor that acts as a master switch in establishing an intricate link between inflammation and cancer. A wide variety of evidence has pointed to a critical role of TNF-α in tumour proliferation, migration, invasion and angiogenesis. The function of TNF-α as a key regulator of the tumour microenvironment is well recognised. We will emphasise the contribution of TNF-α and the nuclear factor-κB pathway on tumour cell invasion and metastasis. Understanding the mechanisms underlying inflammation-mediated metastasis will reveal new therapeutic targets for cancer prevention and treatment. Nature Publishing Group 2010-02-16 2010-01-19 /pmc/articles/PMC2837572/ /pubmed/20087353 http://dx.doi.org/10.1038/sj.bjc.6605530 Text en Copyright © 2010 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Wu, Y
Zhou, B P
TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
title TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
title_full TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
title_fullStr TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
title_full_unstemmed TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
title_short TNF-α/NF-κB/Snail pathway in cancer cell migration and invasion
title_sort tnf-α/nf-κb/snail pathway in cancer cell migration and invasion
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837572/
https://www.ncbi.nlm.nih.gov/pubmed/20087353
http://dx.doi.org/10.1038/sj.bjc.6605530
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