Methotrexate area under the curve is an important outcome predictor in patients with primary CNS lymphoma: A pharmacokinetic–pharmacodynamic analysis from the IELSG no. 20 trial

BACKGROUND: This analysis was initiated to define the predictive value of the area under the curve of high-dose methotrexate (AUC(HD-MTX)) in patients with primary central nervous system lymphoma (PCNSL). PATIENTS AND METHODS: We included 55 patients with PCNSL and available pharmacokinetic (PK) dat...

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Detalles Bibliográficos
Autores principales: Joerger, M, Huitema, A D R, Krähenbühl, S, Schellens, J H M, Cerny, T, Reni, M, Zucca, E, Cavalli, F, Ferreri, A J M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2010
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837574/
https://www.ncbi.nlm.nih.gov/pubmed/20125159
http://dx.doi.org/10.1038/sj.bjc.6605559

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