A False Case of Clozapine-Resistant Schizophrenia

One of the subjects that most concerns physicians is treatment-resistance. About 30%–60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30%...

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Autores principales: Maia-de-Oliveira, J. P., Pinto, J. P., Alexandre, V., Machado-de-Sousa, J. P., Morais, S. L., Chaves, C., Sakamoto, A. C., Zuardi, A. W., Crippa, J. A. S., Hallak, J. E.
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837900/
https://www.ncbi.nlm.nih.gov/pubmed/20300582
http://dx.doi.org/10.1155/2010/534027
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author Maia-de-Oliveira, J. P.
Pinto, J. P.
Alexandre, V.
Machado-de-Sousa, J. P.
Morais, S. L.
Chaves, C.
Sakamoto, A. C.
Zuardi, A. W.
Crippa, J. A. S.
Hallak, J. E.
author_facet Maia-de-Oliveira, J. P.
Pinto, J. P.
Alexandre, V.
Machado-de-Sousa, J. P.
Morais, S. L.
Chaves, C.
Sakamoto, A. C.
Zuardi, A. W.
Crippa, J. A. S.
Hallak, J. E.
author_sort Maia-de-Oliveira, J. P.
collection PubMed
description One of the subjects that most concerns physicians is treatment-resistance. About 30%–60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30% of them do not respond to clozapine either. Here, we describe a patient with an initial diagnosis of refractory schizophrenia who had a history of dramatic aggressiveness. However, in this case, “refractoriness” was a wrong diagnosis. A case of psychosis secondary to epilepsy had been treated as schizophrenia for almost 20 years. Reports like this one are important because they remind us of how a thorough investigation can lead to the correct diagnosis and improve the patient's prognosis.
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spelling pubmed-28379002010-03-18 A False Case of Clozapine-Resistant Schizophrenia Maia-de-Oliveira, J. P. Pinto, J. P. Alexandre, V. Machado-de-Sousa, J. P. Morais, S. L. Chaves, C. Sakamoto, A. C. Zuardi, A. W. Crippa, J. A. S. Hallak, J. E. Case Rep Med Case Report One of the subjects that most concerns physicians is treatment-resistance. About 30%–60% of schizophrenia patients do not respond adequately to antipsychotic treatment and are known as refractory schizophrenia patients. Clozapine has been the drug of choice in such cases. However, approximately 30% of them do not respond to clozapine either. Here, we describe a patient with an initial diagnosis of refractory schizophrenia who had a history of dramatic aggressiveness. However, in this case, “refractoriness” was a wrong diagnosis. A case of psychosis secondary to epilepsy had been treated as schizophrenia for almost 20 years. Reports like this one are important because they remind us of how a thorough investigation can lead to the correct diagnosis and improve the patient's prognosis. Hindawi Publishing Corporation 2010 2010-03-11 /pmc/articles/PMC2837900/ /pubmed/20300582 http://dx.doi.org/10.1155/2010/534027 Text en Copyright © 2010 J. P. Maia-de-Oliveira et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Maia-de-Oliveira, J. P.
Pinto, J. P.
Alexandre, V.
Machado-de-Sousa, J. P.
Morais, S. L.
Chaves, C.
Sakamoto, A. C.
Zuardi, A. W.
Crippa, J. A. S.
Hallak, J. E.
A False Case of Clozapine-Resistant Schizophrenia
title A False Case of Clozapine-Resistant Schizophrenia
title_full A False Case of Clozapine-Resistant Schizophrenia
title_fullStr A False Case of Clozapine-Resistant Schizophrenia
title_full_unstemmed A False Case of Clozapine-Resistant Schizophrenia
title_short A False Case of Clozapine-Resistant Schizophrenia
title_sort false case of clozapine-resistant schizophrenia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2837900/
https://www.ncbi.nlm.nih.gov/pubmed/20300582
http://dx.doi.org/10.1155/2010/534027
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