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The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival
Ca(2+) is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Hindawi Publishing Corporation
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838366/ https://www.ncbi.nlm.nih.gov/pubmed/20300548 http://dx.doi.org/10.1155/2010/546163 |
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author | Cerella, Claudia Diederich, Marc Ghibelli, Lina |
author_facet | Cerella, Claudia Diederich, Marc Ghibelli, Lina |
author_sort | Cerella, Claudia |
collection | PubMed |
description | Ca(2+) is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca(2+) also participates as second messenger. This delineates a dual role for Ca(2+) in cell stress, making difficult to separate the different and multiple mechanisms required for Ca(2+)-mediated control of cell survival and apoptosis. Here we attempt to disentangle the two scenarios, examining on the one side, the events implicated in deregulated Ca(2+) toxicity and the mechanisms through which this elicits reparative or death pathways; on the other, reviewing the role of Ca(2+) as a messenger in the transduction of these same signaling events. |
format | Text |
id | pubmed-2838366 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-28383662010-03-18 The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival Cerella, Claudia Diederich, Marc Ghibelli, Lina Int J Cell Biol Review Article Ca(2+) is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca(2+) also participates as second messenger. This delineates a dual role for Ca(2+) in cell stress, making difficult to separate the different and multiple mechanisms required for Ca(2+)-mediated control of cell survival and apoptosis. Here we attempt to disentangle the two scenarios, examining on the one side, the events implicated in deregulated Ca(2+) toxicity and the mechanisms through which this elicits reparative or death pathways; on the other, reviewing the role of Ca(2+) as a messenger in the transduction of these same signaling events. Hindawi Publishing Corporation 2010 2010-03-15 /pmc/articles/PMC2838366/ /pubmed/20300548 http://dx.doi.org/10.1155/2010/546163 Text en Copyright © 2010 Claudia Cerella et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cerella, Claudia Diederich, Marc Ghibelli, Lina The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival |
title | The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival |
title_full | The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival |
title_fullStr | The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival |
title_full_unstemmed | The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival |
title_short | The Dual Role of Calcium as Messenger and Stressor in Cell Damage, Death, and Survival |
title_sort | dual role of calcium as messenger and stressor in cell damage, death, and survival |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838366/ https://www.ncbi.nlm.nih.gov/pubmed/20300548 http://dx.doi.org/10.1155/2010/546163 |
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