Cargando…

Cytoprotective Effect of the Elongation Factor-2 Kinase-Mediated Autophagy in Breast Cancer Cells Subjected to Growth Factor Inhibition

BACKGROUND: Autophagy is a highly conserved and regulated cellular process employed by living cells to degrade proteins and organelles as a response to metabolic stress. We have previously reported that eukaryotic elongation factor-2 kinase (eEF-2 kinase, also known as Ca(2+)/calmodulin-dependent pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Yan, Li, Huaijun, Ren, Xingcong, Niu, Tingkuang, Hait, William N., Yang, Jinming
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838786/ https://www.ncbi.nlm.nih.gov/pubmed/20300520 http://dx.doi.org/10.1371/journal.pone.0009715

Ejemplares similares

Activity and regulation by growth factors of calmodulin-dependent protein kinase III (elongation factor 2-kinase) in human breast cancer
por: Parmer, T G, et al.
Publicado: (1999)

Insights Into the Pathologic Roles and Regulation of Eukaryotic Elongation Factor-2 Kinase
por: Ballard, Darby J., et al.
Publicado: (2021)

Elongation factor 2 kinase promotes cell survival by inhibiting protein synthesis without inducing autophagy
por: Moore, Claire E.J., et al.
Publicado: (2016)

Cytoprotective roles for autophagy
por: Moreau, Kevin, et al.
Publicado: (2010)

Elongation factor-2 kinase is a critical determinant of the fate and antitumor immunity of CD8(+) T cells
por: Das, Jugal Kishore, et al.
Publicado: (2022)

Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma
por: Liu, Xiao-yuan, et al.
Publicado: (2013)

Doc toxin is a kinase that inactivates elongation factor Tu.
por: Cruz, Jonathan W., et al.
Publicado: (2014)

Targeting Cytoprotective Autophagy to Enhance Anticancer Therapies
por: Xiao, Malina, et al.
Publicado: (2021)

Concomitant Inhibition of Cytoprotective Autophagy Augments the Efficacy of Withaferin A in Hepatocellular Carcinoma
por: Siddharth, Sumit, et al.
Publicado: (2019)

Inhibiting Cytoprotective Autophagy in Cancer Therapy: An Update on Pharmacological Small-Molecule Compounds
por: Zhang, Lijuan, et al.
Publicado: (2022)

Autophagy-competent mitochondrial translation elongation factor TUFM inhibits caspase-8-mediated apoptosis
por: Choi, Chang-Yong, et al.
Publicado: (2021)

Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophagy
por: Guo, Rui, et al.
Publicado: (2016)

EGFR Tyrosine Kinase Inhibitors Activate Autophagy as a Cytoprotective Response in Human Lung Cancer Cells
por: Han, Weidong, et al.
Publicado: (2011)

The Cytoprotective Role of Autophagy in Response to BRAF-Targeted Therapies
por: Elshazly, Ahmed M., et al.
Publicado: (2023)

Eukaryotic elongation factor-2 kinase expression is an independent prognostic factor in colorectal cancer
por: Ng, Tung H., et al.
Publicado: (2019)

Inhibition of JK184-Induced Cytoprotective Autophagy Potentiates JK184 Antitumor Effects in Breast Cancer
por: Xi, Xiaoya, et al.
Publicado: (2020)

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase
por: Pyr Dit Ruys, Sébastien, et al.
Publicado: (2012)

Identification of autophosphorylation sites in eukaryotic elongation factor-2 kinase
por: Ruys, S. Pyr Dit, et al.
Publicado: (2012)

Icaritin Derivative IC2 Induces Cytoprotective Autophagy of Breast Cancer Cells via SCD1 Inhibition
por: Wang, Yi-Xuan, et al.
Publicado: (2023)

Autophagy in human articular chondrocytes is cytoprotective following glucocorticoid stimulation
por: LIU, NING, et al.
Publicado: (2014)

Cytoprotective, Cytotoxic and Cytostatic Roles of Autophagy in Response to BET Inhibitors
por: Elshazly, Ahmed M., et al.
Publicado: (2023)

Targeted Silencing of Elongation Factor 2 Kinase Suppresses Growth and Sensitizes Tumors to Doxorubicin in an Orthotopic Model of Breast Cancer
por: Tekedereli, Ibrahim, et al.
Publicado: (2012)

Integrative roles of transforming growth factor-α in the cytoprotection mechanisms of gastric mucosal injury
por: Kosone, Takashi, et al.
Publicado: (2006)

(V600E)BRAF Inhibition Induces Cytoprotective Autophagy through AMPK in Thyroid Cancer Cells
por: Jiménez-Mora, Eva, et al.
Publicado: (2021)

Asparaginase induces apoptosis and cytoprotective autophagy in chronic myeloid leukemia cells
por: Song, Ping, et al.
Publicado: (2015)

Thiostrepton inhibits stable 70S ribosome binding and ribosome-dependent GTPase activation of elongation factor G and elongation factor 4
por: Walter, Justin D., et al.
Publicado: (2012)

Baicalein induces apoptosis and autophagy of breast cancer cells via inhibiting PI3K/AKT pathway in vivo and vitro
por: Yan, Wanjun, et al.
Publicado: (2018)

Silencing of EEF2K (eukaryotic elongation factor-2 kinase) reveals AMPK-ULK1-dependent autophagy in colon cancer cells
por: Xie, Chuan-Ming, et al.
Publicado: (2014)

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
por: Wang, Xuemin, et al.
Publicado: (2017)

Structural basis for the calmodulin-mediated activation of eukaryotic elongation factor 2 kinase
por: Piserchio, Andrea, et al.
Publicado: (2022)

ADP enhances the allosteric activation of eukaryotic elongation factor 2 kinase by calmodulin
por: Piserchio, Andrea, et al.
Publicado: (2023)

Data regarding the growth of Lactobacillus acidophilus NCFM on different carbohydrates and recombinant production of elongation factor G and pyruvate kinase
por: Celebioglu, Hasan Ufuk, et al.
Publicado: (2017)

Modes of Action of ADP-Ribosylated Elongation Factor 2 in Inhibiting the Polypeptide Elongation Cycle: A Modeling Study
por: Chen, Kevin C., et al.
Publicado: (2013)

Calcineurin suppresses AMPK-dependent cytoprotective autophagy in cardiomyocytes under oxidative stress
por: He, H, et al.
Publicado: (2014)

Cytoprotective effect of flavonoid‐induced autophagy on bisphosphonate mediated cell death in osteoblast
por: Kim, Jung‐Han, et al.
Publicado: (2018)

T-2 Toxin Induces Oxidative Stress, Apoptosis and Cytoprotective Autophagy in Chicken Hepatocytes
por: Yin, Huadong, et al.
Publicado: (2020)

Antrodia salmonea induces apoptosis and enhances cytoprotective autophagy in colon cancer cells
por: Yang, Hsin-Ling, et al.
Publicado: (2021)

High glucose induces an early and transient cytoprotective autophagy in retinal Müller cells
por: Mecchia, A., et al.
Publicado: (2022)

Cytoprotective autophagy as a pro-survival strategy in ART-resistant malaria parasites
por: Kannan, Deepika, et al.
Publicado: (2023)

BAG3 Overexpression and Cytoprotective Autophagy Mediate Apoptosis Resistance in Chemoresistant Breast Cancer Cells
por: Das, Chandan Kanta, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_rvnt6q1pohbgu9t3empdatekq6