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Relevance of Bcl-x expression in different types of endometrial tissues
OBJECTIVES: To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS: RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of va...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838817/ https://www.ncbi.nlm.nih.gov/pubmed/20178603 http://dx.doi.org/10.1186/1756-9966-29-14 |
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author | Ma, Xiaoxin Zhao, Yanhui Li, Yanxia Lu, Hongwei He, Yuanqi |
author_facet | Ma, Xiaoxin Zhao, Yanhui Li, Yanxia Lu, Hongwei He, Yuanqi |
author_sort | Ma, Xiaoxin |
collection | PubMed |
description | OBJECTIVES: To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS: RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types. RESULTS: The Bcl-xl expression levels of simple and atypical hyperplasia endometrial tissues were not significantly different from that of normal endometrial tissue (both P > 0.05). On contrary, Bcl-xl expression in endometrial carcinoma tissue was significantly higher than the normal endometrial tissue (P = 0.00), which was correlated with the pathological grading of endometrial carcinoma (F = 5.33, P = 0.02). In addition, Bcl-xs mRNA level in simple hyperplasia endometrial tissue had no significant difference compared to that in normal endometrial tissue (P = 0.12), while the levels of atypical hyperplasia and endometrial carcinoma endometrial tissues were significantly different from the normal endometrial tissue (both P = 0.00). Furthermore, level of Bcl-xs mRNA was correlated with the clinical staging and lymph node metastasis of the endometrial carcinoma (P < 0.05). The expressions of Bcl-xl and Bcl-xs were negatively correlated with each other (r = -0.76). CONCLUSION: The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma. |
format | Text |
id | pubmed-2838817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-28388172010-03-16 Relevance of Bcl-x expression in different types of endometrial tissues Ma, Xiaoxin Zhao, Yanhui Li, Yanxia Lu, Hongwei He, Yuanqi J Exp Clin Cancer Res Research OBJECTIVES: To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS: RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types. RESULTS: The Bcl-xl expression levels of simple and atypical hyperplasia endometrial tissues were not significantly different from that of normal endometrial tissue (both P > 0.05). On contrary, Bcl-xl expression in endometrial carcinoma tissue was significantly higher than the normal endometrial tissue (P = 0.00), which was correlated with the pathological grading of endometrial carcinoma (F = 5.33, P = 0.02). In addition, Bcl-xs mRNA level in simple hyperplasia endometrial tissue had no significant difference compared to that in normal endometrial tissue (P = 0.12), while the levels of atypical hyperplasia and endometrial carcinoma endometrial tissues were significantly different from the normal endometrial tissue (both P = 0.00). Furthermore, level of Bcl-xs mRNA was correlated with the clinical staging and lymph node metastasis of the endometrial carcinoma (P < 0.05). The expressions of Bcl-xl and Bcl-xs were negatively correlated with each other (r = -0.76). CONCLUSION: The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma. BioMed Central 2010-02-23 /pmc/articles/PMC2838817/ /pubmed/20178603 http://dx.doi.org/10.1186/1756-9966-29-14 Text en Copyright ©2010 Ma et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Ma, Xiaoxin Zhao, Yanhui Li, Yanxia Lu, Hongwei He, Yuanqi Relevance of Bcl-x expression in different types of endometrial tissues |
title | Relevance of Bcl-x expression in different types of endometrial tissues |
title_full | Relevance of Bcl-x expression in different types of endometrial tissues |
title_fullStr | Relevance of Bcl-x expression in different types of endometrial tissues |
title_full_unstemmed | Relevance of Bcl-x expression in different types of endometrial tissues |
title_short | Relevance of Bcl-x expression in different types of endometrial tissues |
title_sort | relevance of bcl-x expression in different types of endometrial tissues |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838817/ https://www.ncbi.nlm.nih.gov/pubmed/20178603 http://dx.doi.org/10.1186/1756-9966-29-14 |
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