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Relevance of Bcl-x expression in different types of endometrial tissues

OBJECTIVES: To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS: RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of va...

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Detalles Bibliográficos
Autores principales: Ma, Xiaoxin, Zhao, Yanhui, Li, Yanxia, Lu, Hongwei, He, Yuanqi
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838817/
https://www.ncbi.nlm.nih.gov/pubmed/20178603
http://dx.doi.org/10.1186/1756-9966-29-14
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author Ma, Xiaoxin
Zhao, Yanhui
Li, Yanxia
Lu, Hongwei
He, Yuanqi
author_facet Ma, Xiaoxin
Zhao, Yanhui
Li, Yanxia
Lu, Hongwei
He, Yuanqi
author_sort Ma, Xiaoxin
collection PubMed
description OBJECTIVES: To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS: RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types. RESULTS: The Bcl-xl expression levels of simple and atypical hyperplasia endometrial tissues were not significantly different from that of normal endometrial tissue (both P > 0.05). On contrary, Bcl-xl expression in endometrial carcinoma tissue was significantly higher than the normal endometrial tissue (P = 0.00), which was correlated with the pathological grading of endometrial carcinoma (F = 5.33, P = 0.02). In addition, Bcl-xs mRNA level in simple hyperplasia endometrial tissue had no significant difference compared to that in normal endometrial tissue (P = 0.12), while the levels of atypical hyperplasia and endometrial carcinoma endometrial tissues were significantly different from the normal endometrial tissue (both P = 0.00). Furthermore, level of Bcl-xs mRNA was correlated with the clinical staging and lymph node metastasis of the endometrial carcinoma (P < 0.05). The expressions of Bcl-xl and Bcl-xs were negatively correlated with each other (r = -0.76). CONCLUSION: The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma.
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spelling pubmed-28388172010-03-16 Relevance of Bcl-x expression in different types of endometrial tissues Ma, Xiaoxin Zhao, Yanhui Li, Yanxia Lu, Hongwei He, Yuanqi J Exp Clin Cancer Res Research OBJECTIVES: To explore the roles of Bcl-xl and Bcl-xs in the development and progression of endometrial carcinoma, and to analyze the correlation between Bcl-xl and Bcl-xs. METHODS: RT-PCR and Western-blot assay were applied to detect the expressions of Bcl-xl and Bcl-xs in endometrial tissues of various histomorphologic types. RESULTS: The Bcl-xl expression levels of simple and atypical hyperplasia endometrial tissues were not significantly different from that of normal endometrial tissue (both P > 0.05). On contrary, Bcl-xl expression in endometrial carcinoma tissue was significantly higher than the normal endometrial tissue (P = 0.00), which was correlated with the pathological grading of endometrial carcinoma (F = 5.33, P = 0.02). In addition, Bcl-xs mRNA level in simple hyperplasia endometrial tissue had no significant difference compared to that in normal endometrial tissue (P = 0.12), while the levels of atypical hyperplasia and endometrial carcinoma endometrial tissues were significantly different from the normal endometrial tissue (both P = 0.00). Furthermore, level of Bcl-xs mRNA was correlated with the clinical staging and lymph node metastasis of the endometrial carcinoma (P < 0.05). The expressions of Bcl-xl and Bcl-xs were negatively correlated with each other (r = -0.76). CONCLUSION: The abnormal expressions of Bcl-xs and Bcl-xl were one of the molecular mechanisms for the pathogenesis of endometrial carcinoma, and altered ratio between these two might involve in the onset of endometrial carcinoma. BioMed Central 2010-02-23 /pmc/articles/PMC2838817/ /pubmed/20178603 http://dx.doi.org/10.1186/1756-9966-29-14 Text en Copyright ©2010 Ma et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Ma, Xiaoxin
Zhao, Yanhui
Li, Yanxia
Lu, Hongwei
He, Yuanqi
Relevance of Bcl-x expression in different types of endometrial tissues
title Relevance of Bcl-x expression in different types of endometrial tissues
title_full Relevance of Bcl-x expression in different types of endometrial tissues
title_fullStr Relevance of Bcl-x expression in different types of endometrial tissues
title_full_unstemmed Relevance of Bcl-x expression in different types of endometrial tissues
title_short Relevance of Bcl-x expression in different types of endometrial tissues
title_sort relevance of bcl-x expression in different types of endometrial tissues
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2838817/
https://www.ncbi.nlm.nih.gov/pubmed/20178603
http://dx.doi.org/10.1186/1756-9966-29-14
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