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Cerebellar vermian hypoplasia in a Cocker Spaniel

An eight-week-old female Cocker Spaniel was presented with ataxia, dysmetria and intention tremor. At 16 weeks, the clinical signs did not progress. Investigation including imaging studies of the skull and cerebrospinal fluid analysis were performed. The computed tomography revealed a cyst-like dila...

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Autores principales: Lim, Ji-Hey, Kim, Dae-Yong, Yoon, Jung-hee, Kim, Wan Hee, Kweon, Oh-kyeong
Formato: Texto
Lenguaje:English
Publicado: The Korean Society of Veterinary Science 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839102/
https://www.ncbi.nlm.nih.gov/pubmed/18487946
http://dx.doi.org/10.4142/jvs.2008.9.2.215
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author Lim, Ji-Hey
Kim, Dae-Yong
Yoon, Jung-hee
Kim, Wan Hee
Kweon, Oh-kyeong
author_facet Lim, Ji-Hey
Kim, Dae-Yong
Yoon, Jung-hee
Kim, Wan Hee
Kweon, Oh-kyeong
author_sort Lim, Ji-Hey
collection PubMed
description An eight-week-old female Cocker Spaniel was presented with ataxia, dysmetria and intention tremor. At 16 weeks, the clinical signs did not progress. Investigation including imaging studies of the skull and cerebrospinal fluid analysis were performed. The computed tomography revealed a cyst-like dilation at the level of the fourth ventricle associated with vermal defect in the cerebellum. After euthanasia, a cerebellar hypoplasia with vermal defect was identified on necropsy. A polymerase chain reaction amplification of cerebellar tissue revealed the absence of an in utero parvoviral infection. Therefore, the cerebellar hypoplasia in this puppy was consistent with diagnosis of primary cerebellar malformation comparable to Dandy-Walker syndrome in humans.
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spelling pubmed-28391022010-03-16 Cerebellar vermian hypoplasia in a Cocker Spaniel Lim, Ji-Hey Kim, Dae-Yong Yoon, Jung-hee Kim, Wan Hee Kweon, Oh-kyeong J Vet Sci Case Report An eight-week-old female Cocker Spaniel was presented with ataxia, dysmetria and intention tremor. At 16 weeks, the clinical signs did not progress. Investigation including imaging studies of the skull and cerebrospinal fluid analysis were performed. The computed tomography revealed a cyst-like dilation at the level of the fourth ventricle associated with vermal defect in the cerebellum. After euthanasia, a cerebellar hypoplasia with vermal defect was identified on necropsy. A polymerase chain reaction amplification of cerebellar tissue revealed the absence of an in utero parvoviral infection. Therefore, the cerebellar hypoplasia in this puppy was consistent with diagnosis of primary cerebellar malformation comparable to Dandy-Walker syndrome in humans. The Korean Society of Veterinary Science 2008-06 2008-06-30 /pmc/articles/PMC2839102/ /pubmed/18487946 http://dx.doi.org/10.4142/jvs.2008.9.2.215 Text en Copyright © 2008 The Korean Society of Veterinary Science https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lim, Ji-Hey
Kim, Dae-Yong
Yoon, Jung-hee
Kim, Wan Hee
Kweon, Oh-kyeong
Cerebellar vermian hypoplasia in a Cocker Spaniel
title Cerebellar vermian hypoplasia in a Cocker Spaniel
title_full Cerebellar vermian hypoplasia in a Cocker Spaniel
title_fullStr Cerebellar vermian hypoplasia in a Cocker Spaniel
title_full_unstemmed Cerebellar vermian hypoplasia in a Cocker Spaniel
title_short Cerebellar vermian hypoplasia in a Cocker Spaniel
title_sort cerebellar vermian hypoplasia in a cocker spaniel
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839102/
https://www.ncbi.nlm.nih.gov/pubmed/18487946
http://dx.doi.org/10.4142/jvs.2008.9.2.215
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