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Tumor-reactive CD4(+) T cells develop cytotoxic activity and eradicate large established melanoma after transfer into lymphopenic hosts

Adoptive transfer of large numbers of tumor-reactive CD8(+) cytotoxic T lymphocytes (CTLs) expanded and differentiated in vitro has shown promising clinical activity against cancer. However, such protocols are complicated by extensive ex vivo manipulations of tumor-reactive cells and have largely fo...

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Detalles Bibliográficos
Autores principales:	Quezada, Sergio A., Simpson, Tyler R., Peggs, Karl S., Merghoub, Taha, Vider, Jelena, Fan, Xiaozhou, Blasberg, Ronald, Yagita, Hideo, Muranski, Pawel, Antony, Paul A., Restifo, Nicholas P., Allison, James P.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2010
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839156/ https://www.ncbi.nlm.nih.gov/pubmed/20156971 http://dx.doi.org/10.1084/jem.20091918

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