Cargando…
Distinct expression and ligand-binding profiles of two constitutively active GPR17 splice variants
BACKGROUND AND PURPOSE: In humans and non-human primates, the 7TM receptor GPR17 exists in two isoforms differing only by the length of the N-terminus. Of these, only the short isoform has previously been characterized. Hence, we investigated gene expression and ligand-binding profiles of both splic...
Autores principales: | Benned-Jensen, T, Rosenkilde, MM |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2010
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839267/ https://www.ncbi.nlm.nih.gov/pubmed/20148890 http://dx.doi.org/10.1111/j.1476-5381.2009.00633.x |
Ejemplares similares
-
The E92K Melanocortin 1 Receptor Mutant Induces cAMP Production and Arrestin Recruitment but Not ERK Activity Indicating Biased Constitutive Signaling
por: Benned-Jensen, Tau, et al.
Publicado: (2011) -
Molecular Characterization of Oxysterol Binding to the Epstein-Barr Virus-induced Gene 2 (GPR183)
por: Benned-Jensen, Tau, et al.
Publicado: (2012) -
Arrestin‐independent constitutive endocytosis of GPR125/ADGRA3
por: Spiess, Katja, et al.
Publicado: (2019) -
Human GPR17 Nonsynonymous Variants Identified in Individuals with Metabolic Diseases Have Distinct Functional Signaling Profiles
por: Conley, Jason M, et al.
Publicado: (2021) -
Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles
por: Conley, Jason M., et al.
Publicado: (2021)