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Role of Surfactant and pH in Dissolution of Curcumin
Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the ba...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications
2009
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839400/ https://www.ncbi.nlm.nih.gov/pubmed/20336212 http://dx.doi.org/10.4103/0250-474X.54280 |
| Sumario: | Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as a dissolution medium. The suitability of dissolution medium (0.5% sodium lauryl sulphate in water) relative to the other dissolution medium was evaluated. The selected dissolution media was used for the evaluation of curcumin tablets. |
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