Role of Surfactant and pH in Dissolution of Curcumin

Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the ba...

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Detalles Bibliográficos
Autores principales: Rahman, S. M. H., Telny, T. C., Ravi, T. K., Kuppusamy, S.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839400/
https://www.ncbi.nlm.nih.gov/pubmed/20336212
http://dx.doi.org/10.4103/0250-474X.54280
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author Rahman, S. M. H.
Telny, T. C.
Ravi, T. K.
Kuppusamy, S.
author_facet Rahman, S. M. H.
Telny, T. C.
Ravi, T. K.
Kuppusamy, S.
author_sort Rahman, S. M. H.
collection PubMed
description Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as a dissolution medium. The suitability of dissolution medium (0.5% sodium lauryl sulphate in water) relative to the other dissolution medium was evaluated. The selected dissolution media was used for the evaluation of curcumin tablets.
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spelling pubmed-28394002010-03-24 Role of Surfactant and pH in Dissolution of Curcumin Rahman, S. M. H. Telny, T. C. Ravi, T. K. Kuppusamy, S. Indian J Pharm Sci Short Communication Curcumin is a phytoconstituent with wide range of biological activity. It is poorly soluble in water. In the present study a new dissolution medium was developed, as there is no validated dissolution method available in the literature. The composition of the dissolution medium was selected on the basis of solubility data at 37°. Solubility data revealed that addition of surfactant may be suitable as a dissolution medium. The suitability of dissolution medium (0.5% sodium lauryl sulphate in water) relative to the other dissolution medium was evaluated. The selected dissolution media was used for the evaluation of curcumin tablets. Medknow Publications 2009 /pmc/articles/PMC2839400/ /pubmed/20336212 http://dx.doi.org/10.4103/0250-474X.54280 Text en © Indian Journal of Pharmaceutical Sciences http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Rahman, S. M. H.
Telny, T. C.
Ravi, T. K.
Kuppusamy, S.
Role of Surfactant and pH in Dissolution of Curcumin
title Role of Surfactant and pH in Dissolution of Curcumin
title_full Role of Surfactant and pH in Dissolution of Curcumin
title_fullStr Role of Surfactant and pH in Dissolution of Curcumin
title_full_unstemmed Role of Surfactant and pH in Dissolution of Curcumin
title_short Role of Surfactant and pH in Dissolution of Curcumin
title_sort role of surfactant and ph in dissolution of curcumin
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839400/
https://www.ncbi.nlm.nih.gov/pubmed/20336212
http://dx.doi.org/10.4103/0250-474X.54280
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AT kuppusamys roleofsurfactantandphindissolutionofcurcumin

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