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Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers
OBJECTIVE: To examine the association between exposure to endotoxins and lung cancer risk by conducting a systematic review and meta-analysis of epidemiologic studies of workers in the cotton textile and agricultural industries; industries known for high exposure levels of endotoxins. METHODS: Risk...
Autores principales: | , , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer Netherlands
2009
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839468/ https://www.ncbi.nlm.nih.gov/pubmed/20012774 http://dx.doi.org/10.1007/s10552-009-9483-z |
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author | Lenters, Virissa Basinas, Ioannis Beane-Freeman, Laura Boffetta, Paolo Checkoway, Harvey Coggon, David Portengen, Lützen Sim, Malcolm Wouters, Inge M. Heederik, Dick Vermeulen, Roel |
author_facet | Lenters, Virissa Basinas, Ioannis Beane-Freeman, Laura Boffetta, Paolo Checkoway, Harvey Coggon, David Portengen, Lützen Sim, Malcolm Wouters, Inge M. Heederik, Dick Vermeulen, Roel |
author_sort | Lenters, Virissa |
collection | PubMed |
description | OBJECTIVE: To examine the association between exposure to endotoxins and lung cancer risk by conducting a systematic review and meta-analysis of epidemiologic studies of workers in the cotton textile and agricultural industries; industries known for high exposure levels of endotoxins. METHODS: Risk estimates were extracted from studies published before 2009 that met predefined quality criteria, including 8 cohort, 1 case–cohort, and 2 case–control studies of cotton textile industry workers, and 15 cohort and 2 case–control studies of agricultural workers. Summary risk estimates were calculated using random effects meta-analyses. Potential sources of heterogeneity were explored through subgroup analyses. RESULTS: The summary risk of lung cancer was 0.72 (95% CI, 0.57–0.90) for textile workers and 0.62 (0.52–0.75) for agricultural workers. The relative risk of lung cancer was below 1.0 for most subgroups defined according to sex, study design, outcome, smoking adjustment, and geographic area. Two studies provided quantitative estimates of endotoxin exposure and both studies tended to support a dose–dependent protective effect of endotoxins on lung cancer risk. CONCLUSION: Despite several limitations, this meta-analysis based on high-quality studies adds weight to the hypothesis that occupational exposure to endotoxin in cotton textile production and agriculture is protective against lung cancer. |
format | Text |
id | pubmed-2839468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-28394682010-03-26 Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers Lenters, Virissa Basinas, Ioannis Beane-Freeman, Laura Boffetta, Paolo Checkoway, Harvey Coggon, David Portengen, Lützen Sim, Malcolm Wouters, Inge M. Heederik, Dick Vermeulen, Roel Cancer Causes Control Original Paper OBJECTIVE: To examine the association between exposure to endotoxins and lung cancer risk by conducting a systematic review and meta-analysis of epidemiologic studies of workers in the cotton textile and agricultural industries; industries known for high exposure levels of endotoxins. METHODS: Risk estimates were extracted from studies published before 2009 that met predefined quality criteria, including 8 cohort, 1 case–cohort, and 2 case–control studies of cotton textile industry workers, and 15 cohort and 2 case–control studies of agricultural workers. Summary risk estimates were calculated using random effects meta-analyses. Potential sources of heterogeneity were explored through subgroup analyses. RESULTS: The summary risk of lung cancer was 0.72 (95% CI, 0.57–0.90) for textile workers and 0.62 (0.52–0.75) for agricultural workers. The relative risk of lung cancer was below 1.0 for most subgroups defined according to sex, study design, outcome, smoking adjustment, and geographic area. Two studies provided quantitative estimates of endotoxin exposure and both studies tended to support a dose–dependent protective effect of endotoxins on lung cancer risk. CONCLUSION: Despite several limitations, this meta-analysis based on high-quality studies adds weight to the hypothesis that occupational exposure to endotoxin in cotton textile production and agriculture is protective against lung cancer. Springer Netherlands 2009-12-12 2010 /pmc/articles/PMC2839468/ /pubmed/20012774 http://dx.doi.org/10.1007/s10552-009-9483-z Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Original Paper Lenters, Virissa Basinas, Ioannis Beane-Freeman, Laura Boffetta, Paolo Checkoway, Harvey Coggon, David Portengen, Lützen Sim, Malcolm Wouters, Inge M. Heederik, Dick Vermeulen, Roel Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers |
title | Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers |
title_full | Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers |
title_fullStr | Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers |
title_full_unstemmed | Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers |
title_short | Endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers |
title_sort | endotoxin exposure and lung cancer risk: a systematic review and meta-analysis of the published literature on agriculture and cotton textile workers |
topic | Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839468/ https://www.ncbi.nlm.nih.gov/pubmed/20012774 http://dx.doi.org/10.1007/s10552-009-9483-z |
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