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Adipocyte extracellular matrix composition, dynamics and role in obesity
The central role of the adipose tissue in lipid metabolism places specific demands on the cell structure of adipocytes. The protein composition and dynamics of the extracellular matrix (ECM) is of crucial importance for the functioning of those cells. Adipogenesis is a bi-phasic process in which the...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
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SP Birkhäuser Verlag Basel
2010
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839497/ https://www.ncbi.nlm.nih.gov/pubmed/20107860 http://dx.doi.org/10.1007/s00018-010-0263-4 |
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author | Mariman, Edwin C. M. Wang, Ping |
author_facet | Mariman, Edwin C. M. Wang, Ping |
author_sort | Mariman, Edwin C. M. |
collection | PubMed |
description | The central role of the adipose tissue in lipid metabolism places specific demands on the cell structure of adipocytes. The protein composition and dynamics of the extracellular matrix (ECM) is of crucial importance for the functioning of those cells. Adipogenesis is a bi-phasic process in which the ECM develops from a fibrillar to a laminar structure as cells move from the commitment phase to the growth phase characterized by storage of vast amounts of triglycerides. Mature adipocytes appear to spend a lot of energy on the maintenance of the ECM. ECM remodeling is mediated by a balanced complement of constructive and destructive enzymes together with their enhancers and inhibitors. ECM remodeling is an energy costing process regulated by insulin, by the energy metabolism, and by mechanical forces. In the obese, overgrowth of adipocytes may lead to instability of the ECM, possibly mediated by hypoxia. |
format | Text |
id | pubmed-2839497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | SP Birkhäuser Verlag Basel |
record_format | MEDLINE/PubMed |
spelling | pubmed-28394972010-03-26 Adipocyte extracellular matrix composition, dynamics and role in obesity Mariman, Edwin C. M. Wang, Ping Cell Mol Life Sci Review The central role of the adipose tissue in lipid metabolism places specific demands on the cell structure of adipocytes. The protein composition and dynamics of the extracellular matrix (ECM) is of crucial importance for the functioning of those cells. Adipogenesis is a bi-phasic process in which the ECM develops from a fibrillar to a laminar structure as cells move from the commitment phase to the growth phase characterized by storage of vast amounts of triglycerides. Mature adipocytes appear to spend a lot of energy on the maintenance of the ECM. ECM remodeling is mediated by a balanced complement of constructive and destructive enzymes together with their enhancers and inhibitors. ECM remodeling is an energy costing process regulated by insulin, by the energy metabolism, and by mechanical forces. In the obese, overgrowth of adipocytes may lead to instability of the ECM, possibly mediated by hypoxia. SP Birkhäuser Verlag Basel 2010-01-27 2010 /pmc/articles/PMC2839497/ /pubmed/20107860 http://dx.doi.org/10.1007/s00018-010-0263-4 Text en © The Author(s) 2010 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Review Mariman, Edwin C. M. Wang, Ping Adipocyte extracellular matrix composition, dynamics and role in obesity |
title | Adipocyte extracellular matrix composition, dynamics and role in obesity |
title_full | Adipocyte extracellular matrix composition, dynamics and role in obesity |
title_fullStr | Adipocyte extracellular matrix composition, dynamics and role in obesity |
title_full_unstemmed | Adipocyte extracellular matrix composition, dynamics and role in obesity |
title_short | Adipocyte extracellular matrix composition, dynamics and role in obesity |
title_sort | adipocyte extracellular matrix composition, dynamics and role in obesity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839497/ https://www.ncbi.nlm.nih.gov/pubmed/20107860 http://dx.doi.org/10.1007/s00018-010-0263-4 |
work_keys_str_mv | AT marimanedwincm adipocyteextracellularmatrixcompositiondynamicsandroleinobesity AT wangping adipocyteextracellularmatrixcompositiondynamicsandroleinobesity |