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Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis

The long latency M2 electromyographic response of a suddenly stretched active muscle is stretch duration dependent of which the nature is unclear. We investigated the influence of the group II afferent blocker tizanidine on M2 response characteristics of the m. flexor carpi radialis (FCR). M2 respon...

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Autores principales: Meskers, Carel G. M., Schouten, Alfred C., Rich, Marieke M. L., de Groot, Jurriaan H., Schuurmans, Jasper, Arendzen, J. H.
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839507/
https://www.ncbi.nlm.nih.gov/pubmed/19940984
http://dx.doi.org/10.1007/s00221-009-2085-x
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author Meskers, Carel G. M.
Schouten, Alfred C.
Rich, Marieke M. L.
de Groot, Jurriaan H.
Schuurmans, Jasper
Arendzen, J. H.
author_facet Meskers, Carel G. M.
Schouten, Alfred C.
Rich, Marieke M. L.
de Groot, Jurriaan H.
Schuurmans, Jasper
Arendzen, J. H.
author_sort Meskers, Carel G. M.
collection PubMed
description The long latency M2 electromyographic response of a suddenly stretched active muscle is stretch duration dependent of which the nature is unclear. We investigated the influence of the group II afferent blocker tizanidine on M2 response characteristics of the m. flexor carpi radialis (FCR). M2 response magnitude and eliciting probability in a group of subjects receiving 4 mg of tizanidine orally were found to be significantly depressed by tizanidine while tizanidine did not affect the significant linear relation of the M2 response to stretch duration. The effect of tizanidine on the M2 response of FCR is supportive of a group II afferent contribution to a compound response of which the stretch duration dependency originates from a different mechanism, e.g., rebound Ia firing.
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spelling pubmed-28395072010-03-26 Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis Meskers, Carel G. M. Schouten, Alfred C. Rich, Marieke M. L. de Groot, Jurriaan H. Schuurmans, Jasper Arendzen, J. H. Exp Brain Res Research Article The long latency M2 electromyographic response of a suddenly stretched active muscle is stretch duration dependent of which the nature is unclear. We investigated the influence of the group II afferent blocker tizanidine on M2 response characteristics of the m. flexor carpi radialis (FCR). M2 response magnitude and eliciting probability in a group of subjects receiving 4 mg of tizanidine orally were found to be significantly depressed by tizanidine while tizanidine did not affect the significant linear relation of the M2 response to stretch duration. The effect of tizanidine on the M2 response of FCR is supportive of a group II afferent contribution to a compound response of which the stretch duration dependency originates from a different mechanism, e.g., rebound Ia firing. Springer-Verlag 2009-11-26 2010 /pmc/articles/PMC2839507/ /pubmed/19940984 http://dx.doi.org/10.1007/s00221-009-2085-x Text en © The Author(s) 2009 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
spellingShingle Research Article
Meskers, Carel G. M.
Schouten, Alfred C.
Rich, Marieke M. L.
de Groot, Jurriaan H.
Schuurmans, Jasper
Arendzen, J. H.
Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis
title Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis
title_full Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis
title_fullStr Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis
title_full_unstemmed Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis
title_short Tizanidine does not affect the linear relation of stretch duration to the long latency M2 response of m. flexor carpi radialis
title_sort tizanidine does not affect the linear relation of stretch duration to the long latency m2 response of m. flexor carpi radialis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839507/
https://www.ncbi.nlm.nih.gov/pubmed/19940984
http://dx.doi.org/10.1007/s00221-009-2085-x
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