An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin

An efficient partial 5-step synthesis of 4′-O-methylquercetin from quercetin in 63% yield is reported. This strategy relies on the selective protection of the catechol group with dichlorodiphenylmethane in diphenyl ether as solvent and on the selective protection of the hydroxyl groups at positions...

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Detalles Bibliográficos
Autores principales: Li, Nian-Guang, Shi, Zhi-Hao, Tang, Yu-Ping, Yang, Jian-Ping, Duan, Jin-Ao
Formato: Texto
Lenguaje:English
Publicado: Beilstein-Institut 2009
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839915/
https://www.ncbi.nlm.nih.gov/pubmed/20300474
http://dx.doi.org/10.3762/bjoc.5.60
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author Li, Nian-Guang
Shi, Zhi-Hao
Tang, Yu-Ping
Yang, Jian-Ping
Duan, Jin-Ao
author_facet Li, Nian-Guang
Shi, Zhi-Hao
Tang, Yu-Ping
Yang, Jian-Ping
Duan, Jin-Ao
author_sort Li, Nian-Guang
collection PubMed
description An efficient partial 5-step synthesis of 4′-O-methylquercetin from quercetin in 63% yield is reported. This strategy relies on the selective protection of the catechol group with dichlorodiphenylmethane in diphenyl ether as solvent and on the selective protection of the hydroxyl groups at positions 3 and 7 with chloromethyl ether.
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spelling pubmed-28399152010-03-17 An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin Li, Nian-Guang Shi, Zhi-Hao Tang, Yu-Ping Yang, Jian-Ping Duan, Jin-Ao Beilstein J Org Chem Full Research Paper An efficient partial 5-step synthesis of 4′-O-methylquercetin from quercetin in 63% yield is reported. This strategy relies on the selective protection of the catechol group with dichlorodiphenylmethane in diphenyl ether as solvent and on the selective protection of the hydroxyl groups at positions 3 and 7 with chloromethyl ether. Beilstein-Institut 2009-11-04 /pmc/articles/PMC2839915/ /pubmed/20300474 http://dx.doi.org/10.3762/bjoc.5.60 Text en Copyright © 2009, Li et al. https://creativecommons.org/licenses/by/2.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Li, Nian-Guang
Shi, Zhi-Hao
Tang, Yu-Ping
Yang, Jian-Ping
Duan, Jin-Ao
An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin
title An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin
title_full An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin
title_fullStr An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin
title_full_unstemmed An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin
title_short An efficient partial synthesis of 4′-O-methylquercetin via regioselective protection and alkylation of quercetin
title_sort efficient partial synthesis of 4′-o-methylquercetin via regioselective protection and alkylation of quercetin
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2839915/
https://www.ncbi.nlm.nih.gov/pubmed/20300474
http://dx.doi.org/10.3762/bjoc.5.60
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