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A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21)
t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphas...
| Autores principales: | , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications
2008
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840780/ https://www.ncbi.nlm.nih.gov/pubmed/20300287 http://dx.doi.org/10.4103/0971-6866.42323 |
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| author | Trivedi, P. J. Patel, P. S. Brahmbhatt, M. M Patel, B. P. Gajjar, S. B. Iyer, R. R. Parikh, E. H. Shukla, S. N. Shah, P. M. Bakshi, S. R. |
| author_facet | Trivedi, P. J. Patel, P. S. Brahmbhatt, M. M Patel, B. P. Gajjar, S. B. Iyer, R. R. Parikh, E. H. Shukla, S. N. Shah, P. M. Bakshi, S. R. |
| author_sort | Trivedi, P. J. |
| collection | PubMed |
| description | t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphase results of AML-ETO fusion was positive and trisomy of 4 was confirmed with WCP probes. Trisomy 4 in AML with t(8;21) is a rare numerical abnormality. Here we present such case of patient which may constitute a distinctive subtype. |
| format | Text |
| id | pubmed-2840780 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2008 |
| publisher | Medknow Publications |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28407802010-03-18 A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) Trivedi, P. J. Patel, P. S. Brahmbhatt, M. M Patel, B. P. Gajjar, S. B. Iyer, R. R. Parikh, E. H. Shukla, S. N. Shah, P. M. Bakshi, S. R. Indian J Hum Genet Case Report t(8;21)(q22;q22) is the most frequently observed karyotypic abnormality associated with acute myeloid leukemia (AML), specifically in FAB-M2. Short-term unstimulated bone marrow (BM) and peripheral blood lymphocyte culture showed 47,XX, +4,t(8;21) in all metaphase plates; and interphase and metaphase results of AML-ETO fusion was positive and trisomy of 4 was confirmed with WCP probes. Trisomy 4 in AML with t(8;21) is a rare numerical abnormality. Here we present such case of patient which may constitute a distinctive subtype. Medknow Publications 2008 /pmc/articles/PMC2840780/ /pubmed/20300287 http://dx.doi.org/10.4103/0971-6866.42323 Text en © Indian Journal of Human Genetics http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Case Report Trivedi, P. J. Patel, P. S. Brahmbhatt, M. M Patel, B. P. Gajjar, S. B. Iyer, R. R. Parikh, E. H. Shukla, S. N. Shah, P. M. Bakshi, S. R. A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) |
| title | A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) |
| title_full | A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) |
| title_fullStr | A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) |
| title_full_unstemmed | A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) |
| title_short | A case of acute myeloid leukemia-M2 with trisomy 4 in addition to t(8;21) |
| title_sort | case of acute myeloid leukemia-m2 with trisomy 4 in addition to t(8;21) |
| topic | Case Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840780/ https://www.ncbi.nlm.nih.gov/pubmed/20300287 http://dx.doi.org/10.4103/0971-6866.42323 |
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