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Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India

BACKGROUND: The presence of anti-HBc IgG in the absence of HBsAg is usually indicative of a past self-limiting HBV infection. But it is frequently associated with co-infection with HCV which can worsen the existing status of chronic liver disease (CLD). OBJECTIVES: The present study was planned to e...

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Autores principales: Jain, Manisha, Chakravarti, Anita, Kar, P
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840942/
https://www.ncbi.nlm.nih.gov/pubmed/20300383
http://dx.doi.org/10.4103/0974-777X.52978
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author Jain, Manisha
Chakravarti, Anita
Kar, P
author_facet Jain, Manisha
Chakravarti, Anita
Kar, P
author_sort Jain, Manisha
collection PubMed
description BACKGROUND: The presence of anti-HBc IgG in the absence of HBsAg is usually indicative of a past self-limiting HBV infection. But it is frequently associated with co-infection with HCV which can worsen the existing status of chronic liver disease (CLD). OBJECTIVES: The present study was planned to evaluate the significance of isolated HBc IgG positivity in patients of CLD and look for the presence of HCV co-infection in such patients. METHODS: Clinical profiles and biochemical tests were done for all the 77 CLD cases included in the study. Blood samples were taken from these patients and tested by the commercially available EIA for the presence of HBsAg, anti-HBc IgG, anti-HBs and anti-HCV. HBV DNA was detected by amplifying the surface region in all the cases. RESULTS: Isolated anti-HBc IgG positivity defined as the presence of anti-HBc IgG in absence of any other serological markers of HBV infection was detected in 28 patients. Out of 64 patients positive for anti-HBc IgG 36 had the markers of HBV, either HBsAg, HBV DNA or anti-HBs alone or in combination. There was a significant association between isolated anti-HBc IgG positivity and HCV co-infection. CONCLUSION: Anti-HBc IgG should be tested in all patients with CLD as it is frequently the only marker of HBV infection in such patients and they should be monitored closely as such patients can develop CLD. Presence of co-infection with HCV should be actively searched for in such patients.
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spelling pubmed-28409422010-03-18 Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India Jain, Manisha Chakravarti, Anita Kar, P J Glob Infect Dis Clinical Investigation BACKGROUND: The presence of anti-HBc IgG in the absence of HBsAg is usually indicative of a past self-limiting HBV infection. But it is frequently associated with co-infection with HCV which can worsen the existing status of chronic liver disease (CLD). OBJECTIVES: The present study was planned to evaluate the significance of isolated HBc IgG positivity in patients of CLD and look for the presence of HCV co-infection in such patients. METHODS: Clinical profiles and biochemical tests were done for all the 77 CLD cases included in the study. Blood samples were taken from these patients and tested by the commercially available EIA for the presence of HBsAg, anti-HBc IgG, anti-HBs and anti-HCV. HBV DNA was detected by amplifying the surface region in all the cases. RESULTS: Isolated anti-HBc IgG positivity defined as the presence of anti-HBc IgG in absence of any other serological markers of HBV infection was detected in 28 patients. Out of 64 patients positive for anti-HBc IgG 36 had the markers of HBV, either HBsAg, HBV DNA or anti-HBs alone or in combination. There was a significant association between isolated anti-HBc IgG positivity and HCV co-infection. CONCLUSION: Anti-HBc IgG should be tested in all patients with CLD as it is frequently the only marker of HBV infection in such patients and they should be monitored closely as such patients can develop CLD. Presence of co-infection with HCV should be actively searched for in such patients. Medknow Publications 2009 /pmc/articles/PMC2840942/ /pubmed/20300383 http://dx.doi.org/10.4103/0974-777X.52978 Text en © Journal of Global Infectious Diseases http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Investigation
Jain, Manisha
Chakravarti, Anita
Kar, P
Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India
title Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India
title_full Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India
title_fullStr Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India
title_full_unstemmed Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India
title_short Clinical Significance of Isolated Anti-HBc Positivity in Cases of Chronic Liver Disease in New Delhi, India
title_sort clinical significance of isolated anti-hbc positivity in cases of chronic liver disease in new delhi, india
topic Clinical Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2840942/
https://www.ncbi.nlm.nih.gov/pubmed/20300383
http://dx.doi.org/10.4103/0974-777X.52978
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