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Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature

BACKGROUND: Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral complications is sparse. Here we will review the literature and describe the orofaci...

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Autores principales: Dar-Odeh, Najla S, Hayajneh, Wail A, Abu-Hammad, Osama A, Hammad, Huda M, Al-Wahadneh, Adel M, Bulos, Najwa K, Mahafzah, Azmi M, Shomaf, Maha S, El-Maaytah, Mohammed A, Bakri, Faris G
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841072/
https://www.ncbi.nlm.nih.gov/pubmed/20163723
http://dx.doi.org/10.1186/1756-0500-3-37
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author Dar-Odeh, Najla S
Hayajneh, Wail A
Abu-Hammad, Osama A
Hammad, Huda M
Al-Wahadneh, Adel M
Bulos, Najwa K
Mahafzah, Azmi M
Shomaf, Maha S
El-Maaytah, Mohammed A
Bakri, Faris G
author_facet Dar-Odeh, Najla S
Hayajneh, Wail A
Abu-Hammad, Osama A
Hammad, Huda M
Al-Wahadneh, Adel M
Bulos, Najwa K
Mahafzah, Azmi M
Shomaf, Maha S
El-Maaytah, Mohammed A
Bakri, Faris G
author_sort Dar-Odeh, Najla S
collection PubMed
description BACKGROUND: Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral complications is sparse. Here we will review the literature and describe the orofacial findings in 12 patients. FINDINGS: The age range was 5-31 years. Oral findings were variable, and reflected a low level of oral hygiene. They included periodontitis, rampant caries, gingivitis, aphthous-like ulcers, and geographic tongue. One patient had white patches on the buccal mucosa similar to lichen planus. Another patient had a nodular dorsum of the tongue associated with fissured and geographic tongue. Biopsies from the latter two lesions revealed chronic non-specific mucositis. Panoramic radiographs showed extensive periodontitis in one patient and periapical lesions in another patient. CONCLUSION: Patients with chronic granulomatous disease may develop oral lesions reflecting susceptibility to infections and inflammation. It is also possible that social and genetic factors may influence the development of this complication. Therefore, oral hygiene must be kept at an optimum level to prevent infections that can be difficult to manage.
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spelling pubmed-28410722010-03-18 Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature Dar-Odeh, Najla S Hayajneh, Wail A Abu-Hammad, Osama A Hammad, Huda M Al-Wahadneh, Adel M Bulos, Najwa K Mahafzah, Azmi M Shomaf, Maha S El-Maaytah, Mohammed A Bakri, Faris G BMC Res Notes Short Report BACKGROUND: Chronic granulomatous disease is an extremely rare primary immunodeficiency syndrome that can be associated with various oral complications. This can affect high number of patients. However, data on oral complications is sparse. Here we will review the literature and describe the orofacial findings in 12 patients. FINDINGS: The age range was 5-31 years. Oral findings were variable, and reflected a low level of oral hygiene. They included periodontitis, rampant caries, gingivitis, aphthous-like ulcers, and geographic tongue. One patient had white patches on the buccal mucosa similar to lichen planus. Another patient had a nodular dorsum of the tongue associated with fissured and geographic tongue. Biopsies from the latter two lesions revealed chronic non-specific mucositis. Panoramic radiographs showed extensive periodontitis in one patient and periapical lesions in another patient. CONCLUSION: Patients with chronic granulomatous disease may develop oral lesions reflecting susceptibility to infections and inflammation. It is also possible that social and genetic factors may influence the development of this complication. Therefore, oral hygiene must be kept at an optimum level to prevent infections that can be difficult to manage. BioMed Central 2010-02-17 /pmc/articles/PMC2841072/ /pubmed/20163723 http://dx.doi.org/10.1186/1756-0500-3-37 Text en Copyright ©2010 Dar-Odeh et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Report
Dar-Odeh, Najla S
Hayajneh, Wail A
Abu-Hammad, Osama A
Hammad, Huda M
Al-Wahadneh, Adel M
Bulos, Najwa K
Mahafzah, Azmi M
Shomaf, Maha S
El-Maaytah, Mohammed A
Bakri, Faris G
Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature
title Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature
title_full Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature
title_fullStr Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature
title_full_unstemmed Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature
title_short Orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature
title_sort orofacial findings in chronic granulomatous disease: report of twelve patients and review of the literature
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841072/
https://www.ncbi.nlm.nih.gov/pubmed/20163723
http://dx.doi.org/10.1186/1756-0500-3-37
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