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New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study
Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ∼4,800 Japan...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
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Public Library of Science
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841168/ https://www.ncbi.nlm.nih.gov/pubmed/20305777 http://dx.doi.org/10.1371/journal.pone.0009723 |
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| author | Nakajima, Masahiro Takahashi, Atsushi Kou, Ikuyo Rodriguez-Fontenla, Cristina Gomez-Reino, Juan J. Furuichi, Tatsuya Dai, Jin Sudo, Akihiro Uchida, Atsumasa Fukui, Naoshi Kubo, Michiaki Kamatani, Naoyuki Tsunoda, Tatsuhiko Malizos, Konstantinos N. Tsezou, Aspasia Gonzalez, Antonio Nakamura, Yusuke Ikegawa, Shiro |
| author_facet | Nakajima, Masahiro Takahashi, Atsushi Kou, Ikuyo Rodriguez-Fontenla, Cristina Gomez-Reino, Juan J. Furuichi, Tatsuya Dai, Jin Sudo, Akihiro Uchida, Atsumasa Fukui, Naoshi Kubo, Michiaki Kamatani, Naoyuki Tsunoda, Tatsuhiko Malizos, Konstantinos N. Tsezou, Aspasia Gonzalez, Antonio Nakamura, Yusuke Ikegawa, Shiro |
| author_sort | Nakajima, Masahiro |
| collection | PubMed |
| description | Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ∼4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10(−8) for rs7775228 and 6.73×10(−8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA. |
| format | Text |
| id | pubmed-2841168 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2010 |
| publisher | Public Library of Science |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-28411682010-03-20 New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study Nakajima, Masahiro Takahashi, Atsushi Kou, Ikuyo Rodriguez-Fontenla, Cristina Gomez-Reino, Juan J. Furuichi, Tatsuya Dai, Jin Sudo, Akihiro Uchida, Atsumasa Fukui, Naoshi Kubo, Michiaki Kamatani, Naoyuki Tsunoda, Tatsuhiko Malizos, Konstantinos N. Tsezou, Aspasia Gonzalez, Antonio Nakamura, Yusuke Ikegawa, Shiro PLoS One Research Article Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ∼4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43×10(−8) for rs7775228 and 6.73×10(−8) for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA. Public Library of Science 2010-03-18 /pmc/articles/PMC2841168/ /pubmed/20305777 http://dx.doi.org/10.1371/journal.pone.0009723 Text en Nakajima et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
| spellingShingle | Research Article Nakajima, Masahiro Takahashi, Atsushi Kou, Ikuyo Rodriguez-Fontenla, Cristina Gomez-Reino, Juan J. Furuichi, Tatsuya Dai, Jin Sudo, Akihiro Uchida, Atsumasa Fukui, Naoshi Kubo, Michiaki Kamatani, Naoyuki Tsunoda, Tatsuhiko Malizos, Konstantinos N. Tsezou, Aspasia Gonzalez, Antonio Nakamura, Yusuke Ikegawa, Shiro New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study |
| title | New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study |
| title_full | New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study |
| title_fullStr | New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study |
| title_full_unstemmed | New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study |
| title_short | New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study |
| title_sort | new sequence variants in hla class ii/iii region associated with susceptibility to knee osteoarthritis identified by genome-wide association study |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841168/ https://www.ncbi.nlm.nih.gov/pubmed/20305777 http://dx.doi.org/10.1371/journal.pone.0009723 |
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