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Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor

In this study we wanted to gain insights into selectivity mechanisms between G-protein-coupled receptors (GPCR) and different subtypes of G-proteins. The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (IP). Our goal was to dissect selectivity patterns...

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Detalles Bibliográficos
Autores principales:	Kleinau, Gunnar, Jaeschke, Holger, Worth, Catherine L., Mueller, Sandra, Gonzalez, Jorge, Paschke, Ralf, Krause, Gerd
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2010
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841179/ https://www.ncbi.nlm.nih.gov/pubmed/20305779 http://dx.doi.org/10.1371/journal.pone.0009745

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