Is cytochrome modulation the new frontier for decreasing the risk of cataract?

AIM: The present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm. MATERIALS AND METHODS: Macroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily;...

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Detalles Bibliográficos
Autores principales: Nair, Kavitha S., Patel, Kirti V., Gandhi, Tejal R.
Formato: Texto
Lenguaje:English
Publicado: Medknow Publications 2009
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841236/
https://www.ncbi.nlm.nih.gov/pubmed/20336221
http://dx.doi.org/10.4103/0253-7613.51344
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author Nair, Kavitha S.
Patel, Kirti V.
Gandhi, Tejal R.
author_facet Nair, Kavitha S.
Patel, Kirti V.
Gandhi, Tejal R.
author_sort Nair, Kavitha S.
collection PubMed
description AIM: The present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm. MATERIALS AND METHODS: Macroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily; PO) showed delayed occurrence of cataract while pioglitazone (3.8 mg/kg; once daily; PO) pretreatment demonstrated an early cataract. RESULTS AND CONCLUSION: A delayed occurrence of cataract with diltiazem (CYP inhibitor) and an early onset of cataract with pioglitazone (CYP inducer) indicate that a cytochrome P450 mediated pathway may affect the initiation of cataract but not the maturation pattern.
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spelling pubmed-28412362010-03-24 Is cytochrome modulation the new frontier for decreasing the risk of cataract? Nair, Kavitha S. Patel, Kirti V. Gandhi, Tejal R. Indian J Pharmacol Research Article AIM: The present study was designed to study the effect of cytochrome P450 (CYP) modulators on the occurrence of cataract using male Sprague-Dawley rats weighing 40:50 gm. MATERIALS AND METHODS: Macroscopical examination of the lens isolated from rats pretreated with diltiazem (30 mg/kg; once daily; PO) showed delayed occurrence of cataract while pioglitazone (3.8 mg/kg; once daily; PO) pretreatment demonstrated an early cataract. RESULTS AND CONCLUSION: A delayed occurrence of cataract with diltiazem (CYP inhibitor) and an early onset of cataract with pioglitazone (CYP inducer) indicate that a cytochrome P450 mediated pathway may affect the initiation of cataract but not the maturation pattern. Medknow Publications 2009-04 /pmc/articles/PMC2841236/ /pubmed/20336221 http://dx.doi.org/10.4103/0253-7613.51344 Text en © Indian Journal of Pharmacology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Nair, Kavitha S.
Patel, Kirti V.
Gandhi, Tejal R.
Is cytochrome modulation the new frontier for decreasing the risk of cataract?
title Is cytochrome modulation the new frontier for decreasing the risk of cataract?
title_full Is cytochrome modulation the new frontier for decreasing the risk of cataract?
title_fullStr Is cytochrome modulation the new frontier for decreasing the risk of cataract?
title_full_unstemmed Is cytochrome modulation the new frontier for decreasing the risk of cataract?
title_short Is cytochrome modulation the new frontier for decreasing the risk of cataract?
title_sort is cytochrome modulation the new frontier for decreasing the risk of cataract?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841236/
https://www.ncbi.nlm.nih.gov/pubmed/20336221
http://dx.doi.org/10.4103/0253-7613.51344
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