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The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies

It is well admitted that the link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways, which act during the different steps of tumorigenesis. The cyclooxygenases (COXs) are a family of enzymes, which catalyze the rate-limiting step of prostaglandin biosy...

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Autores principales: Sobolewski, Cyril, Cerella, Claudia, Dicato, Mario, Ghibelli, Lina, Diederich, Marc
Formato: Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841246/
https://www.ncbi.nlm.nih.gov/pubmed/20339581
http://dx.doi.org/10.1155/2010/215158
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author Sobolewski, Cyril
Cerella, Claudia
Dicato, Mario
Ghibelli, Lina
Diederich, Marc
author_facet Sobolewski, Cyril
Cerella, Claudia
Dicato, Mario
Ghibelli, Lina
Diederich, Marc
author_sort Sobolewski, Cyril
collection PubMed
description It is well admitted that the link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways, which act during the different steps of tumorigenesis. The cyclooxygenases (COXs) are a family of enzymes, which catalyze the rate-limiting step of prostaglandin biosynthesis. This family contains three members: ubiquitously expressed COX-1, which is involved in homeostasis; the inducible COX-2 isoform, which is upregulated during both inflammation and cancer; and COX-3, expressed in brain and spinal cord, whose functions remain to be elucidated. COX-2 was described to modulate cell proliferation and apoptosis mainly in solid tumors, that is, colorectal, breast, and prostate cancers, and, more recently, in hematological malignancies. These findings prompt us to analyze here the effects of a combination of COX-2 inhibitors together with different clinically used therapeutic strategies in order to further improve the efficiency of future anticancer treatments. COX-2 modulation is a promising field investigated by many research groups.
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spelling pubmed-28412462010-03-25 The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies Sobolewski, Cyril Cerella, Claudia Dicato, Mario Ghibelli, Lina Diederich, Marc Int J Cell Biol Review Article It is well admitted that the link between chronic inflammation and cancer involves cytokines and mediators of inflammatory pathways, which act during the different steps of tumorigenesis. The cyclooxygenases (COXs) are a family of enzymes, which catalyze the rate-limiting step of prostaglandin biosynthesis. This family contains three members: ubiquitously expressed COX-1, which is involved in homeostasis; the inducible COX-2 isoform, which is upregulated during both inflammation and cancer; and COX-3, expressed in brain and spinal cord, whose functions remain to be elucidated. COX-2 was described to modulate cell proliferation and apoptosis mainly in solid tumors, that is, colorectal, breast, and prostate cancers, and, more recently, in hematological malignancies. These findings prompt us to analyze here the effects of a combination of COX-2 inhibitors together with different clinically used therapeutic strategies in order to further improve the efficiency of future anticancer treatments. COX-2 modulation is a promising field investigated by many research groups. Hindawi Publishing Corporation 2010 2010-03-17 /pmc/articles/PMC2841246/ /pubmed/20339581 http://dx.doi.org/10.1155/2010/215158 Text en Copyright © 2010 Cyril Sobolewski et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Sobolewski, Cyril
Cerella, Claudia
Dicato, Mario
Ghibelli, Lina
Diederich, Marc
The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
title The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
title_full The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
title_fullStr The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
title_full_unstemmed The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
title_short The Role of Cyclooxygenase-2 in Cell Proliferation and Cell Death in Human Malignancies
title_sort role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841246/
https://www.ncbi.nlm.nih.gov/pubmed/20339581
http://dx.doi.org/10.1155/2010/215158
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