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Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility
In the process of inflammation and repair of the intestinal mucosa in inflammatory bowel disease (IBD), there occurs a complex and an unknown interplay of innate and adaptive immune mechanisms. This interaction of factors may explain why IBD is characterized by a relapsing and remitting clinical cou...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Medknow Publications
2009
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841424/ https://www.ncbi.nlm.nih.gov/pubmed/19636186 http://dx.doi.org/10.4103/1319-3767.54742 |
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author | Barahona-Garrido, Josué Hernández-Calleros, Jorge García-Juárez, Ignacio Yamamoto-Furusho, Jesús K. |
author_facet | Barahona-Garrido, Josué Hernández-Calleros, Jorge García-Juárez, Ignacio Yamamoto-Furusho, Jesús K. |
author_sort | Barahona-Garrido, Josué |
collection | PubMed |
description | In the process of inflammation and repair of the intestinal mucosa in inflammatory bowel disease (IBD), there occurs a complex and an unknown interplay of innate and adaptive immune mechanisms. This interaction of factors may explain why IBD is characterized by a relapsing and remitting clinical course. Different components of innate immunity, hormones and interleukins in IBD have been suggested to be impaired. The growth hormone, epidermal growth factor, keratinocyte growth factor and colony-stimulating factors have emerged as potential tools for the modulation of intestinal inflammation and repair. Despite promising results of initial studies, the evidence that justify treatment of patients in clinical practice is not enough as some of the trials are nonrandomized or included a small number of patients. In this concise review, we provide a summary of the most recent and relevant evidence regarding the potential therapeutic effects of growth factors in IBD. |
format | Text |
id | pubmed-2841424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2009 |
publisher | Medknow Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-28414242010-03-24 Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility Barahona-Garrido, Josué Hernández-Calleros, Jorge García-Juárez, Ignacio Yamamoto-Furusho, Jesús K. Saudi J Gastroenterol New Horizon In the process of inflammation and repair of the intestinal mucosa in inflammatory bowel disease (IBD), there occurs a complex and an unknown interplay of innate and adaptive immune mechanisms. This interaction of factors may explain why IBD is characterized by a relapsing and remitting clinical course. Different components of innate immunity, hormones and interleukins in IBD have been suggested to be impaired. The growth hormone, epidermal growth factor, keratinocyte growth factor and colony-stimulating factors have emerged as potential tools for the modulation of intestinal inflammation and repair. Despite promising results of initial studies, the evidence that justify treatment of patients in clinical practice is not enough as some of the trials are nonrandomized or included a small number of patients. In this concise review, we provide a summary of the most recent and relevant evidence regarding the potential therapeutic effects of growth factors in IBD. Medknow Publications 2009-07 /pmc/articles/PMC2841424/ /pubmed/19636186 http://dx.doi.org/10.4103/1319-3767.54742 Text en © Saudi Journal of Gastroenterology http://creativecommons.org/licenses/by/2.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | New Horizon Barahona-Garrido, Josué Hernández-Calleros, Jorge García-Juárez, Ignacio Yamamoto-Furusho, Jesús K. Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility |
title | Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility |
title_full | Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility |
title_fullStr | Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility |
title_full_unstemmed | Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility |
title_short | Growth Factors as Treatment for Inflammatory Bowel Disease: A Concise Review of the Evidence Toward Their Potential Clinical Utility |
title_sort | growth factors as treatment for inflammatory bowel disease: a concise review of the evidence toward their potential clinical utility |
topic | New Horizon |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841424/ https://www.ncbi.nlm.nih.gov/pubmed/19636186 http://dx.doi.org/10.4103/1319-3767.54742 |
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