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Mad2-induced chromosome instability leads to lung tumor relapse after oncogene withdrawal
Inhibition of an initiating oncogene often leads to extensive tumor cell death, a phenomenon known as oncogene addiction1. This has led to the search for compounds that specifically target and inhibit oncogenes as anti-cancer agents. Whether chromosomal instability (CIN) generated as a result of der...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841716/ https://www.ncbi.nlm.nih.gov/pubmed/20173739 http://dx.doi.org/10.1038/nature08803 |