The carboxy-terminal fragment of α(1A) calcium channel preferentially aggregates in the cytoplasm of human spinocerebellar ataxia type 6 Purkinje cells

Spinocerebellar ataxia type 6 (SCA6) is an autosomal dominant neurodegenerative disease caused by a small polyglutamine (polyQ) expansion (control: 4–20Q; SCA6: 20–33Q) in the carboxyl(C)-terminal cytoplasmic domain of the α(1A) voltage-dependent calcium channel (Ca(v)2.1). Although a 75–85-kDa Ca(v...

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Detalles Bibliográficos
Autores principales: Ishiguro, Taro, Ishikawa, Kinya, Takahashi, Makoto, Obayashi, Masato, Amino, Takeshi, Sato, Nozomu, Sakamoto, Masaki, Fujigasaki, Hiroto, Tsuruta, Fuminori, Dolmetsch, Ricardo, Arai, Takao, Sasaki, Hidenao, Nagashima, Kazuro, Kato, Takeo, Yamada, Mitsunori, Takahashi, Hitoshi, Hashizume, Yoshio, Mizusawa, Hidehiro
Formato: Texto
Lenguaje:English
Publicado: Springer-Verlag 2009
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841749/
https://www.ncbi.nlm.nih.gov/pubmed/20043227
http://dx.doi.org/10.1007/s00401-009-0630-0

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